Protein Classes
Protein Summary
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000219476
- ENSP00000219476
- ENSG00000103197
- ENST00000350773
- ENSP00000344383
- ENST00000382538
- ENSP00000371978
- ENST00000401874
- ENSP00000384468
- ENST00000439673
- ENSP00000399232
- ENST00000642936
- ENSP00000494514
- ENST00000644043
- ENSP00000496262
- TSC4
- LAM
- TSC4
- PPP1R160
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
biological process | 0.99 | ||
biological term | 0.98 | ||
disease perturbation | 0.9 | ||
kinase | 0.9 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1084.59 (req: < 5)
Gene RIFs: 254 (req: <= 3)
Antibodies: 1854 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1084.59 (req: >= 5)
Gene RIFs: 254 (req: > 3)
Antibodies: 1854 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (73)
Reactome (23)
KEGG (15)
PathwayCommons (13)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 23
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AKT phosphorylates targets in the cytosol | ||||
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Constitutive Signaling by AKT1 E17K in Cancer | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AKT phosphorylates targets in the cytosol | ||||
Autophagy | ||||
Cellular responses to external stimuli | ||||
Constitutive Signaling by AKT1 E17K in Cancer | ||||
Disease | ||||
Gene Ontology Terms (38)
Functions (5)
Components (9)
Processes (24)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (301)
1 – 10 of 301
COL20A1
Novelty: 1.49268293
p_int: 0.9997743
p_ni: 0.000225691
p_wrong: 9e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
CD79B
Novelty: 0.00265318
p_int: 0.99975998
p_ni: 0.000239989
p_wrong: 3.1e-8
Data Source: BioPlex
TBC1D7
Novelty: 0.14796765
p_int: 0.998400748
p_ni: 0.001599251
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PNKD
Family: Enzyme
Novelty: 0.01082297
p_int: 0.998229984
p_ni: 0.001770004
p_wrong: 1.2e-8
Data Source: BioPlex
MORF4L1
Family: Epigenetic
Novelty: 0.02624863
p_int: 0.99575212
p_ni: 0.00424788
Data Source: BioPlex
CD226
Novelty: 0.00453644
p_int: 0.992623556
p_ni: 0.007376444
Data Source: BioPlex
PRKCSH
Family: Enzyme
Novelty: 0.00609928
p_int: 0.990608065
p_ni: 0.009391648
p_wrong: 2.86e-7
Score: 0.266
Data Source: BioPlex,STRINGDB
SEMA4C
Novelty: 0.01413319
p_int: 0.98289715
p_ni: 0.017102849
p_wrong: 1e-9
Data Source: BioPlex
CD83
Novelty: 0.00171116
p_int: 0.968181557
p_ni: 0.031818443
Data Source: BioPlex
TMEM9
Novelty: 0.1192335
p_int: 0.967897613
p_ni: 0.032102385
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score 1084.59
PubMed score by year
PubTator Score 765.58
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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