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Tbio
TSC2
Tuberin

Protein Summary
Description
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219476
  • ENSP00000219476
  • ENSG00000103197
  • ENST00000350773
  • ENSP00000344383
  • ENST00000382538
  • ENSP00000371978
  • ENST00000401874
  • ENSP00000384468
  • ENST00000439673
  • ENSP00000399232
  • ENST00000642936
  • ENSP00000494514
  • ENST00000644043
  • ENSP00000496262

Symbol
  • TSC4
  • LAM
  • TSC4
  • PPP1R160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.99
biological term
0.98
disease perturbation
0.9
kinase
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1084.59   (req: < 5)
Gene RIFs: 254   (req: <= 3)
Antibodies: 1854   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1084.59   (req: >= 5)
Gene RIFs: 254   (req: > 3)
Antibodies: 1854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (73)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

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Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Disease
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Autophagy
Cellular responses to external stimuli
Constitutive Signaling by AKT1 E17K in Cancer
Disease
Gene Ontology Terms (38)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (301)
1 – 10 of 301
COL20A1
Tdark
Novelty: 1.49268293
p_int: 0.9997743
p_ni: 0.000225691
p_wrong: 9e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
CD79B
Tclin
Novelty: 0.00265318
p_int: 0.99975998
p_ni: 0.000239989
p_wrong: 3.1e-8
Data Source: BioPlex
TBC1D7
Tbio
Novelty: 0.14796765
p_int: 0.998400748
p_ni: 0.001599251
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PNKD
Tbio
Family: Enzyme
Novelty: 0.01082297
p_int: 0.998229984
p_ni: 0.001770004
p_wrong: 1.2e-8
Data Source: BioPlex
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.02624863
p_int: 0.99575212
p_ni: 0.00424788
Data Source: BioPlex
CD226
Tbio
Novelty: 0.00453644
p_int: 0.992623556
p_ni: 0.007376444
Data Source: BioPlex
PRKCSH
Tbio
Family: Enzyme
Novelty: 0.00609928
p_int: 0.990608065
p_ni: 0.009391648
p_wrong: 2.86e-7
Score: 0.266
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01413319
p_int: 0.98289715
p_ni: 0.017102849
p_wrong: 1e-9
Data Source: BioPlex
CD83
Tbio
Novelty: 0.00171116
p_int: 0.968181557
p_ni: 0.031818443
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.1192335
p_int: 0.967897613
p_ni: 0.032102385
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1084.59

PubMed score by year
PubTator Score  765.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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