Tbio RGS7 Regulator of G-protein signaling 7

Protein Summary

Description

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).

Uniprot Accession IDs

• P49802
• Q5T3H4
• Q8TD66
• Q8TD67
• Q8WW09
• Q9UNU7
• Q9Y6B9
• RGS7

Gene Name

• RGS7

Ensembl ID

• ENST00000348120
• ENSP00000341242
• ENSG00000182901
• ENST00000366563
• ENSP00000355521
• ENST00000366564
• ENSP00000355522
• ENST00000366565
• ENSP00000355523

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
co-expressed gene	0.79
protein domain	0.73
gene perturbation	0.71
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.57   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.57   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0