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Tbio
RGS7
Regulator of G-protein signaling 7

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348120
  • ENSP00000341242
  • ENSG00000182901
  • ENST00000366563
  • ENSP00000355521
  • ENST00000366564
  • ENSP00000355522
  • ENST00000366565
  • ENSP00000355523
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
co-expressed gene
0.79
protein domain
0.73
gene perturbation
0.71
disease perturbation
0.68


Related Tools
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.99   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.99   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 7
VGNC:6984
469729
Macaque
regulator of G protein signaling 7
707747
Mouse
MGI:1346089
24012
Rat
RGD:3570
54296
Dog
regulator of G protein signaling 7
VGNC:45536
100687600
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 7
Macaque
regulator of G protein signaling 7
Mouse
Rat
Dog
regulator of G protein signaling 7
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49802-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G alpha (i) signalling events
GPCR downstream signalling
Metabolism of proteins
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (106)
1 – 10 of 106
GNB5
Tbio
Novelty: 0.0067714
p_int: 0.999998375
p_ni: 5.08e-7
p_wrong: 0.000001117
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCT5
Tbio
Novelty: 0.02369118
Score: 0.999
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.981
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.968
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.95
Data Source: STRINGDB
RGS7BP
Tbio
Novelty: 0.05820527
Score: 0.948
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.934
Data Source: STRINGDB
PDCL
Tbio
Novelty: 0.00317454
Score: 0.933
Data Source: STRINGDB
RGS11
Tbio
Novelty: 0.02181028
Score: 0.919
Data Source: STRINGDB
RGS9
Tbio
Novelty: 0.06662559
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.99

PubMed score by year
PubTator Score  27.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer