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Tchem
RGS19
Regulator of G-protein signaling 19

Protein Summary
Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332298
  • ENSP00000333194
  • ENSG00000171700
  • ENST00000395042
  • ENSP00000378483

Symbol
  • GAIP
  • GNAI3IP
  • GAIP
  • RGSGAIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.95
cellular component
0.69
transcription factor perturbation
0.68
tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.69   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.69   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1917204
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
35.5
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
35.5
1
20.5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
G alpha (z) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (z) signalling events
GPCR downstream signalling
Signal Transduction
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (40)
1 – 10 of 40
RGS20
Tbio
Novelty: 0.04087618
p_int: 0.999767098
p_ni: 1.65e-7
p_wrong: 0.000232736
Score: 0.216
Data Source: BioPlex,STRINGDB
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.972698082
p_ni: 0.00002988
p_wrong: 0.027272037
Score: 0.188
Data Source: BioPlex,STRINGDB
GIPC1
Tbio
Novelty: 0.00862
Score: 0.997
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.986
Data Source: STRINGDB
GNAZ
Tbio
Novelty: 0.02008523
Score: 0.981
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.978
Data Source: STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.973
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.964
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.952
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.69

PubMed score by year
PubTator Score  27.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer