Tbio NUP153 Nuclear pore complex protein Nup153

Protein Summary

Description

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• P49790
• B4DIK2
• E7EPX5
• F6QR24
• Q4LE47
• Q5T9I7
• Q7Z743

Gene Name

• NUP153

Ensembl ID

• ENST00000262077
• ENSP00000262077
• ENSG00000124789
• ENST00000537253
• ENSP00000444029
• ENST00000613258
• ENSP00000478627

Symbol

• N153
• HNUP153

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.99
transcription factor binding site profile	0.98
drug perturbation	0.96
biological process	0.85
cellular component	0.85

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.85   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.85   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (263)

Explore Interacting Targets

1 – 10 of 263

• See Interactions on String-DB

NUP50

Tbio

Novelty:  0.03424725

p_int:  0.999734833

p_ni:  0.000265167

Score:  0.999

Data Source:  BioPlex,STRINGDB

RAN

Tchem

Family:  Enzyme

Novelty:  0.00160888

p_int:  0.998703133

p_ni:  0.001296867

Score:  0.995

Data Source:  BioPlex,STRINGDB

KPNA2

Tbio

Novelty:  0.00506958

p_int:  0.998310668

p_ni:  0.001689332

Score:  0.994

Data Source:  BioPlex,STRINGDB

NXF2

Tbio

Novelty:  0.04733504

p_int:  0.923089965

p_ni:  0.076910035

Score:  0.859

Data Source:  BioPlex,STRINGDB

SREK1IP1

Tdark

Novelty:  1.39429464

p_int:  0.896144971

p_ni:  0.103855029

p_wrong:  1e-9

Score:  0.175

Data Source:  BioPlex,STRINGDB

PPP1CA

Tchem

Family:  Enzyme

Novelty:  0.00354658

p_int:  0.89027547

p_ni:  0.10972453

Score:  0.17

Data Source:  BioPlex,STRINGDB

TSR1

Tbio

Novelty:  0.01639069

p_int:  0.880250668

p_ni:  0.119749332

Score:  0.307

Data Source:  BioPlex,STRINGDB

PPP1CC

Tchem

Family:  Enzyme

Novelty:  0.00465946

p_int:  0.864581109

p_ni:  0.135418891

Score:  0.23

Data Source:  BioPlex,STRINGDB

G3BP2

Tbio

Family:  Enzyme

Novelty:  0.04786241

p_int:  0.838680456

p_ni:  0.161319544

Score:  0.382

Data Source:  BioPlex,STRINGDB

NUSAP1

Tbio

Novelty:  0.01702118

p_int:  0.783235129

p_ni:  0.216764871

Score:  0.221

Data Source:  BioPlex,STRINGDB

Pathways (75)

Reactome (68)

KEGG (1)

PathwayCommons (5)

WikiPathways (1)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Gene Ontology Terms (23)

Functions (6)

Components (10)

Processes (7)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
structural constituent of nuclear pore	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein membrane anchor	Inferred from Mutant Phenotype (IMP)	UniProtKB
nuclear localization sequence binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
DNA-binding
Glycoprotein
Host-virus interaction
Isopeptide bond
Membrane

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 153	VGNC:3600	462455
Macaque	nucleoporin 153		703888
Mouse	nucleoporin 153	MGI:2385621	218210
Rat	nucleoporin 153	RGD:3216	25281
Dog	nucleoporin 153		478732

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 153
Macaque	nucleoporin 153
Mouse	nucleoporin 153
Rat	nucleoporin 153
Dog	nucleoporin 153

Publication Statistics

PubMed Score 143.85

PubMed score by year

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PubTator Score 84.79

PubTator score by year

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