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Tbio
FLT3LG
Fms-related tyrosine kinase 3 ligand

Protein Summary
Description
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204637
  • ENSP00000204637
  • ENSG00000090554
  • ENST00000594009
  • ENSP00000469613
  • ENST00000595510
  • ENSP00000471226
  • ENST00000597551
  • ENSP00000468977
  • ENST00000600429
  • ENSP00000470453

Symbol
  • FL
  • FLG3L
  • FLT3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
histone modification site profile
0.67
transcription factor binding site profile
0.66
transcription factor
0.64
biological term
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.64   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.64   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0