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Tbio
EIF2B2
Translation initiation factor eIF-2B subunit beta

Protein Summary
Description
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266126
  • ENSP00000266126
  • ENSG00000119718

Symbol
  • EIF2BB
  • EIF2B
  • EIF-2Bbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
molecular function
0.98
transcription factor perturbation
0.94
interacting protein
0.81


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.6   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.6   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit beta
VGNC:3439
453042
Macaque
eukaryotic translation initiation factor 2B subunit beta
701360
Mouse
MGI:2145118
217715
Rat
RGD:620820
84005
Dog
eukaryotic translation initiation factor 2B subunit beta
VGNC:40261
490789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit beta
Macaque
eukaryotic translation initiation factor 2B subunit beta
Mouse
Rat
Dog
eukaryotic translation initiation factor 2B subunit beta
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49770-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Cap-dependent Translation Initiation (R-HSA-72737)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Metabolism of proteins
Reactome
Recycling of eIF2:GDP
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Metabolism of proteins
Recycling of eIF2:GDP
Translation
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (101)
1 – 10 of 101
EIF2B1
Tbio
Novelty: 0.02520554
p_int: 0.999999856
p_ni: 1.44e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
p_int: 0.999999759
p_ni: 1.57e-7
p_wrong: 8.4e-8
Data Source: BioPlex
EIF2B4
Tbio
Novelty: 0.05080792
p_int: 0.999998801
p_ni: 0.000001199
Score: 0.996
Data Source: BioPlex,STRINGDB
EIF2B3
Tbio
Novelty: 0.04963646
p_int: 0.999997448
p_ni: 0.000002552
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.999996886
p_ni: 0.000003112
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOG
Tbio
Family: Enzyme
Novelty: 0.03588463
p_int: 0.999827737
p_ni: 0.000172263
Data Source: BioPlex
BTC
Tbio
Novelty: 0.00673076
p_int: 0.999312914
p_ni: 0.000687086
Data Source: BioPlex
GYPB
Tbio
Novelty: 0.00442195
p_int: 0.998938505
p_ni: 0.001061495
Data Source: BioPlex
CD226
Tbio
Novelty: 0.00374102
p_int: 0.996856858
p_ni: 0.003143142
Data Source: BioPlex
GOLM1
Tbio
Novelty: 0.00752112
p_int: 0.996788243
p_ni: 0.003211757
Data Source: BioPlex
Publication Statistics
PubMed Score  28.60

PubMed score by year
PubTator Score  12.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer