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Tchem
PSEN1
Presenilin-1

Protein Summary
Description
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324501
  • ENSP00000326366
  • ENSG00000080815
  • ENST00000357710
  • ENSP00000350342
  • ENST00000394157
  • ENSP00000377712
  • ENST00000394164
  • ENSP00000377719
  • ENST00000553855
  • ENSP00000452242
  • ENST00000555386
  • ENSP00000450845
  • ENST00000557511
  • ENSP00000451429

Symbol
  • AD3
  • PS1
  • PSNL1
  • AD3
  • FAD
  • PS1
  • PS-1
  • S182
  • ACNINV3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.98
molecular function
0.94
disease perturbation
0.93
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1933.18   (req: < 5)
Gene RIFs: 498   (req: <= 3)
Antibodies: 853   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1933.18   (req: >= 5)
Gene RIFs: 498   (req: > 3)
Antibodies: 853   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 91
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0