Protein Summary
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314) ...more
- ENST00000324501
- ENSP00000326366
- ENSG00000080815
- ENST00000357710
- ENSP00000350342
- ENST00000394157
- ENSP00000377712
- ENST00000394164
- ENSP00000377719
- ENST00000553855
- ENSP00000452242
- ENST00000555386
- ENSP00000450845
- ENST00000557511
- ENSP00000451429
- AD3
- PS1
- PSNL1
- AD3
- FAD
- PS1
- PS-1
- S182
- ACNINV3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 0.98 | ||
molecular function | 0.94 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4470.62 (req: < 5)
Gene RIFs: 498 (req: <= 3)
Antibodies: 853 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4470.62 (req: >= 5)
Gene RIFs: 498 (req: > 3)
Antibodies: 853 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 84
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 91
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (91)
Protein-Protein Interactions (319)
SPPL2B
Family: Enzyme
Novelty: 0.0274774
p_int: 0.919532316
p_ni: 0.080467683
Score: 0.458
Data Source: BioPlex,STRINGDB
AIRE
Family: TF; Epigenetic
Novelty: 0.00158659
p_int: 0.889469508
p_ni: 0.110530492
Data Source: BioPlex
CDH8
Novelty: 0.04055999
p_int: 0.789766622
p_ni: 0.210233377
Score: 0.27
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (57)
Reactome (35)
KEGG (5)
PathwayCommons (13)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Viral Interactions (0)
Gene Ontology Terms (115)
Functions (7)
Components (31)
Processes (77)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 2 | 2 | 75.4 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 72.3 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 51.7 | |||||
HbA1c measurement | 1 | 1 | 1 | 47.7 | |||||
cognitive function measurement | 2 | 1 | 2 | 44.2 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 75.4 | |||||
C-reactive protein measurement | 1 | 72.3 | |||||
alkaline phosphatase measurement | 1 | 51.7 | |||||
HbA1c measurement | 1 | 47.7 | |||||
cognitive function measurement | 2 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | presenilin 1 | VGNC:3326 | 739740 | |||||
Macaque | presenilin 1 | 696274 | ||||||
Mouse | MGI:1202717 | 19164 | ||||||
Rat | RGD:3425 | 29192 | ||||||
Dog | presenilin 1 | VGNC:45085 | 403408 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | presenilin 1 | |||||
Macaque | presenilin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | presenilin 1 | |||||
Publication Statistics
PubMed Score 4470.62
PubMed score by year
PubTator Score 1744.28
PubTator score by year
Related Publications
Text Mined References (682)
GeneRif Annotations (498)
Items per page:
0 of 0
PMID | Year | Title |
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