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Tclin
VEGFB
Vascular endothelial growth factor B

Protein Summary
Description
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309422
  • ENSP00000311127
  • ENSG00000173511
  • ENST00000426086
  • ENSP00000401550

Symbol
  • VRF
  • VRF
  • VEGFL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.88
tissue sample
0.79
gene perturbation
0.76
small molecule perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.93   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 560   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.93   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 560   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
aflibercept
no chemical structure image available
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
92.6
waist-hip ratio
1
1
1
87.2
triglyceride measurement
2
1
2
76.1
eosinophil count
2
1
2
62.6
high density lipoprotein cholesterol measurement
1
1
1
59.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
92.6
waist-hip ratio
1
87.2
triglyceride measurement
2
76.1
eosinophil count
2
62.6
high density lipoprotein cholesterol measurement
1
59.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vascular endothelial growth factor B
VGNC:943
741897
Macaque
vascular endothelial growth factor B
722115
Mouse
MGI:106199
22340
Rat
RGD:619799
89811
Dog
vascular endothelial growth factor B
VGNC:48251
476036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vascular endothelial growth factor B
Macaque
vascular endothelial growth factor B
Mouse
Rat
Dog
vascular endothelial growth factor B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49765-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Signal Transduction
Gene Ontology Terms (36)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (122)
1 – 10 of 122
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.999911489
p_ni: 0.000088511
Score: 0.163
Data Source: BioPlex,STRINGDB
ADAM21
Tdark
Family: Enzyme
Novelty: 0.16068055
p_int: 0.999896768
p_ni: 0.000020752
p_wrong: 0.00008248
Score: 0.167
Data Source: BioPlex,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
p_int: 0.999876188
p_ni: 9.61e-7
p_wrong: 0.000122851
Score: 0.958
Data Source: BioPlex,STRINGDB
LY86
Tbio
Novelty: 0.00314575
p_int: 0.999636023
p_ni: 0.000041017
p_wrong: 0.00032296
Data Source: BioPlex
HAL
Tbio
Family: Enzyme
Novelty: 0.01504631
p_int: 0.907466923
p_ni: 0.092533066
p_wrong: 1.1e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
NUDT16L1
Tbio
Novelty: 0.05291665
p_int: 0.750814652
p_ni: 0.249185348
Score: 0.282
Data Source: BioPlex,STRINGDB
FLT1
Tclin
Family: Kinase
Novelty: 0.00039648
Score: 0.999
Data Source: Reactome,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.953
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.941
Data Source: STRINGDB
HGF
Tchem
Family: Enzyme
Novelty: 0.00035574
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  285.93

PubMed score by year
PubTator Score  165.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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