Protein Classes
Protein Summary
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
- ENST00000405431
- ENSP00000385365
- ENSG00000119630
- ENST00000553716
- ENSP00000451413
- ENST00000555567
- ENSP00000451040
- PGFL
- PLGF
- PGFL
- PIGF
- PLGF
- PlGF-2
- D12S1900
- SHGC-10760
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.97 | ||
PubMedID | 0.69 | ||
disease | 0.65 | ||
biological process | 0.6 | ||
tissue | 0.57 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1914.71 (req: < 5)
Gene RIFs: 297 (req: <= 3)
Antibodies: 860 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1914.71 (req: >= 5)
Gene RIFs: 297 (req: > 3)
Antibodies: 860 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (16)
1 – 10 of 16
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 2 | 45.9 | ||||||
bone density | 1 | 1 | 1 | 21.7 | |||||
heel bone mineral density | 1 | 1 | 1 | 9.8 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 45.9 | ||||||
bone density | 1 | 21.7 | |||||
heel bone mineral density | 1 | 9.8 | |||||
Orthologs (10)
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Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | placental growth factor | VGNC:3348 | 741830 | |||||
Macaque | placental growth factor | 701219 | ||||||
Mouse | MGI:105095 | 18654 | ||||||
Rat | RGD:619850 | 94203 | ||||||
Dog | placental growth factor | VGNC:44457 | 100855780 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | placental growth factor | |||||
Macaque | placental growth factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | placental growth factor | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (5)
KEGG (6)
PathwayCommons (2)
WikiPathways (4)
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Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Reactome | Signaling by VEGF | ||||
Reactome | VEGF binds to VEGFR leading to receptor dimerization | ||||
Reactome | VEGF ligand-receptor interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Signaling by VEGF | ||||
VEGF binds to VEGFR leading to receptor dimerization | ||||
VEGF ligand-receptor interactions | ||||
Gene Ontology Terms (30)
Functions (6)
Components (3)
Processes (21)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (153)
1 – 10 of 153
FLT1
Family: Kinase
Novelty: 0.00039648
Score: 0.999
Data Source: Reactome,STRINGDB
KDR
Family: Kinase
Novelty: 0.00016219
Score: 0.984
Data Source: STRINGDB
VEGFA
Novelty: 0.0000378
Score: 0.954
Data Source: STRINGDB
VEGFC
Novelty: 0.00077508
Score: 0.927
Data Source: STRINGDB
VEGFD
Novelty: 0.00233128
Score: 0.926
Data Source: STRINGDB
VEGFB
Novelty: 0.00293322
Score: 0.922
Data Source: STRINGDB
PIK3CA
Family: Kinase
Novelty: 0.00044273
Score: 0.915
Data Source: STRINGDB
FLT4
Family: Kinase
Novelty: 0.001296
Score: 0.91
Data Source: STRINGDB
PIK3R1
Family: Kinase
Novelty: 0.00179772
Score: 0.906
Data Source: STRINGDB
PLCG1
Family: Enzyme
Novelty: 0.00110273
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score 1914.71
PubMed score by year
PubTator Score 1605.97
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword