Protein Classes
Protein Summary
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
- ENST00000405431
- ENSP00000385365
- ENSG00000119630
- ENST00000553716
- ENSP00000451413
- ENST00000555567
- ENSP00000451040
- PGFL
- PLGF
- PGFL
- PIGF
- PLGF
- PlGF-2
- D12S1900
- SHGC-10760
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.97 | ||
PubMedID | 0.69 | ||
disease | 0.65 | ||
biological process | 0.6 | ||
tissue | 0.57 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3621.51 (req: < 5)
Gene RIFs: 297 (req: <= 3)
Antibodies: 860 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3621.51 (req: >= 5)
Gene RIFs: 297 (req: > 3)
Antibodies: 860 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (16)
1 – 10 of 16
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (17)
Reactome (5)
KEGG (6)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Reactome | Signaling by VEGF | ||||
Reactome | VEGF binds to VEGFR leading to receptor dimerization | ||||
Reactome | VEGF ligand-receptor interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Signal Transduction | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Signaling by VEGF | ||||
VEGF binds to VEGFR leading to receptor dimerization | ||||
VEGF ligand-receptor interactions | ||||
Gene Ontology Terms (30)
Functions (6)
Components (3)
Processes (21)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (153)
1 – 10 of 153
FLT1
Family: Kinase
Novelty: 0.00037168
Score: 0.999
Data Source: Reactome,STRINGDB
KDR
Family: Kinase
Novelty: 0.00019671
Score: 0.984
Data Source: STRINGDB
VEGFA
Novelty: 0.00004909
Score: 0.954
Data Source: STRINGDB
VEGFC
Novelty: 0.00094058
Score: 0.927
Data Source: STRINGDB
VEGFD
Novelty: 0.00329663
Score: 0.926
Data Source: STRINGDB
VEGFB
Novelty: 0.00363465
Score: 0.922
Data Source: STRINGDB
PIK3CA
Family: Kinase
Novelty: 0.00077082
Score: 0.915
Data Source: STRINGDB
FLT4
Family: Kinase
Novelty: 0.00175479
Score: 0.91
Data Source: STRINGDB
PIK3R1
Family: Kinase
Novelty: 0.00286014
Score: 0.906
Data Source: STRINGDB
PLCG1
Family: Enzyme
Novelty: 0.00125418
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score 3621.51
PubMed score by year
PubTator Score 1605.97
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVE
1-70
HMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPD
70-140
MPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMK
140-210
PERCGDAVPRR
210-221
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
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