Tclin PGF Placenta growth factor

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Placenta Growth Factor

DTO Classes

Protein / Signaling / Growth Factor / Placenta Growth Factor

Protein Summary

Description

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• P49763
• Q07101
• Q9BV78
• Q9Y6S8
• PlGF

Gene Name

• PGF

Ensembl ID

• ENST00000405431
• ENSP00000385365
• ENSG00000119630
• ENST00000553716
• ENSP00000451413
• ENST00000555567
• ENSP00000451040

Symbol

• PGFL
• PLGF
• PGFL
• PIGF
• PLGF
• PlGF-2
• D12S1900
• SHGC-10760

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.97
PubMedID	0.69
disease	0.65
biological process	0.6
tissue	0.57

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3621.51   (req: < 5)

Gene RIFs: 297   (req: <= 3)

Antibodies: 860   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3621.51   (req: >= 5)

Gene RIFs: 297   (req: > 3)

Antibodies: 860   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

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1 – 1 of 1

aflibercept

PGFTclin

INHIBITOR Kd: 10.40893555

Active Ligands (16)

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1 – 10 of 16

CHEMBL1689460

PGFTclin

Kd: 8.4

CHEMBL63354

PGFTclin

Kd: 8.09

CHEMBL1689483

PGFTclin

Kd: 10

CHEMBL1689481

PGFTclin

Kd: 9.52

CHEMBL2335722

PGFTclin

Kd: 7.96

CHEMBL499587

PGFTclin

Kd: 7.64

CHEMBL1689482

PGFTclin

Kd: 8.1

CHEMBL450916

PGFTclin

Kd: 6.41

CHEMBL1689463

PGFTclin

Kd: 8.3

CHEMBL1689461

PGFTclin

Kd: 6.7

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (17)

Reactome (5)

KEGG (6)

PathwayCommons (2)

WikiPathways (4)

Signal Transduction (R-HSA-162582)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934
Reactome	Signaling by VEGF	103 targets	R-HSA-194138
Reactome	VEGF binds to VEGFR leading to receptor dimerization	8 targets	R-HSA-195399
Reactome	VEGF ligand-receptor interactions	8 targets	R-HSA-194313

Name	Explore in Pharos	Explore in Source
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934
Signaling by VEGF	103 targets	R-HSA-194138
VEGF binds to VEGFR leading to receptor dimerization	8 targets	R-HSA-195399
VEGF ligand-receptor interactions	8 targets	R-HSA-194313

Gene Ontology Terms (30)

Functions (6)

Components (3)

Processes (21)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
growth factor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
chemoattractant activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
vascular endothelial growth factor receptor 3 binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
heparin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein homodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (153)

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1 – 10 of 153

• See Interactions on String-DB

FLT1

Tclin

Family: Kinase

Novelty: 0.00037168

Score: 0.999

Data Source: Reactome,STRINGDB

KDR

Tclin

Family: Kinase

Novelty: 0.00019671

Score: 0.984

Data Source: STRINGDB

VEGFA

Tclin

Novelty: 0.00004909

Score: 0.954

Data Source: STRINGDB

VEGFC

Tbio

Novelty: 0.00094058

Score: 0.927

Data Source: STRINGDB

VEGFD

Tbio

Novelty: 0.00329663

Score: 0.926

Data Source: STRINGDB

VEGFB

Tclin

Novelty: 0.00363465

Score: 0.922

Data Source: STRINGDB

PIK3CA

Tclin

Family: Kinase

Novelty: 0.00077082

Score: 0.915

Data Source: STRINGDB

FLT4

Tclin

Family: Kinase

Novelty: 0.00175479

Score: 0.91

Data Source: STRINGDB

PIK3R1

Tchem

Family: Kinase

Novelty: 0.00286014

Score: 0.906

Data Source: STRINGDB

PLCG1

Tchem

Family: Enzyme

Novelty: 0.00125418

Score: 0.902

Data Source: STRINGDB

Publication Statistics

PubMed Score  3621.51

PubMed score by year

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PubTator Score  1605.97

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Amino Acid Sequence

Residue Counts

Sequence

MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVE

1-70

HMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPD

70-140

MPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMK

140-210

PERCGDAVPRR

210-221

MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR

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Uniprot Keyword

3D-structure
Alternative splicing
Angiogenesis
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor