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Tclin
PGF
Placenta growth factor

Protein Summary
Description
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405431
  • ENSP00000385365
  • ENSG00000119630
  • ENST00000553716
  • ENSP00000451413
  • ENST00000555567
  • ENSP00000451040

Symbol
  • PGFL
  • PLGF
  • PGFL
  • PIGF
  • PLGF
  • PlGF-2
  • D12S1900
  • SHGC-10760
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
PubMedID
0.69
disease
0.65
biological process
0.6
tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1914.71   (req: < 5)
Gene RIFs: 297   (req: <= 3)
Antibodies: 860   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1914.71   (req: >= 5)
Gene RIFs: 297   (req: > 3)
Antibodies: 860   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
aflibercept
no chemical structure image available
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
45.9
bone density
1
1
1
21.7
heel bone mineral density
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
45.9
bone density
1
21.7
heel bone mineral density
1
9.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
placental growth factor
VGNC:3348
741830
Macaque
placental growth factor
701219
Mouse
MGI:105095
18654
Rat
RGD:619850
94203
Dog
placental growth factor
VGNC:44457
100855780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
placental growth factor
Macaque
placental growth factor
Mouse
Rat
Dog
placental growth factor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by VEGF
Reactome
VEGF binds to VEGFR leading to receptor dimerization
Reactome
VEGF ligand-receptor interactions
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by VEGF
VEGF binds to VEGFR leading to receptor dimerization
VEGF ligand-receptor interactions
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (153)
1 – 10 of 153
FLT1
Tclin
Family: Kinase
Novelty: 0.00039648
Score: 0.999
Data Source: Reactome,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.984
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.954
Data Source: STRINGDB
VEGFC
Tbio
Novelty: 0.00077508
Score: 0.927
Data Source: STRINGDB
VEGFD
Tbio
Novelty: 0.00233128
Score: 0.926
Data Source: STRINGDB
VEGFB
Tclin
Novelty: 0.00293322
Score: 0.922
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.915
Data Source: STRINGDB
FLT4
Tclin
Family: Kinase
Novelty: 0.001296
Score: 0.91
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.906
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  1914.71

PubMed score by year
PubTator Score  1605.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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