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Tchem
CLK3
Dual specificity protein kinase CLK3

Protein Summary
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345005
  • ENSP00000344112
  • ENSG00000179335
  • ENST00000395066
  • ENSP00000378505
  • ENST00000483723
  • ENSP00000431825

Symbol
  • PHCLK3
  • PHCLK3/152
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
molecular function
0.96
ligand (protein) perturbation
0.83
virus perturbation
0.83
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
caffeine metabolite measurement
2
1
0
6.3
61
Cleft palate
1
1
0
1.2
57.3
1
1
0
1.2
57.3
bladder carcinoma
1
1
0
1.4
53.3
cups of coffee per day measurement
1
1
1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
caffeine metabolite measurement
0
6.3
61
Cleft palate
0
1.2
57.3
0
1.2
57.3
bladder carcinoma
0
1.4
53.3
cups of coffee per day measurement
1
32.9
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (102)
1 – 10 of 102
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.999997329
p_ni: 0.000002671
Data Source: BioPlex
GPATCH8
Tdark
Novelty: 0.45717416
p_int: 0.999994711
p_ni: 0.000005289
Score: 0.699
Data Source: BioPlex,STRINGDB
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.999991456
p_ni: 0.000008544
Score: 0.589
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.999991414
p_ni: 0.000008586
Data Source: BioPlex
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999990115
p_ni: 0.000009885
Score: 0.561
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999987196
p_ni: 0.000012804
Data Source: BioPlex
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999982392
p_ni: 0.000017608
Score: 0.189
Data Source: BioPlex,STRINGDB
USP9Y
Tdark
Family: Enzyme
p_int: 0.999931946
p_ni: 0.000068054
Data Source: BioPlex
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.999928388
p_ni: 0.000071612
Score: 0.648
Data Source: BioPlex,STRINGDB
PRPF38B
Tdark
Novelty: 1.02626586
p_int: 0.99990702
p_ni: 0.000077571
p_wrong: 0.000015409
Score: 0.707
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.20

PubMed score by year
PubTator Score  10.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer