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Tchem
CLK1
Dual specificity protein kinase CLK1

Protein Summary
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321356
  • ENSP00000326830
  • ENSG00000013441
  • ENST00000432425
  • ENSP00000400487
  • ENST00000434813
  • ENSP00000394734

Symbol
  • CLK
  • CLK
  • STY
  • CLK/STY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.98
molecular function
0.95
disease perturbation
0.87
phenotype
0.78
small molecule perturbation
0.78


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.64   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.64   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
sunitinib
chemical structure image
nintedanib
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDC like kinase 1
VGNC:141
459865
Macaque
CDC like kinase 1
700320
Mouse
MGI:107403
12747
Rat
RGD:1311469
301434
Dog
CDC like kinase 1
VGNC:39346
478866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDC like kinase 1
Macaque
CDC like kinase 1
Mouse
Rat
Dog
CDC like kinase 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (81)
1 – 10 of 81
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.999950438
p_ni: 0.000048724
p_wrong: 8.38e-7
Score: 0.72
Data Source: BioPlex,STRINGDB
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.999867294
p_ni: 0.000132706
Score: 0.758
Data Source: BioPlex,STRINGDB
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999835497
p_ni: 0.000164456
p_wrong: 4.7e-8
Score: 0.613
Data Source: BioPlex,STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.99949612
p_ni: 0.000503877
p_wrong: 3e-9
Data Source: BioPlex
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.961
Data Source: STRINGDB
CLK4
Tchem
Family: Kinase
Novelty: 0.04183341
Score: 0.956
Data Source: STRINGDB
PRPF39
Tdark
Novelty: 0.35760414
Score: 0.854
Data Source: STRINGDB
CCNL1
Tbio
Novelty: 0.07551385
Score: 0.818
Data Source: STRINGDB
SRSF5
Tbio
Novelty: 0.01658346
Score: 0.806
Data Source: STRINGDB
RBM23
Tbio
Novelty: 0.03769792
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.64

PubMed score by year
PubTator Score  84.66

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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