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Tchem
CLK1
Dual specificity protein kinase CLK1

Protein Summary
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321356
  • ENSP00000326830
  • ENSG00000013441
  • ENST00000432425
  • ENSP00000400487
  • ENST00000434813
  • ENSP00000394734

Symbol
  • CLK
  • CLK
  • STY
  • CLK/STY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.98
molecular function
0.95
disease perturbation
0.87
phenotype
0.78
small molecule perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.89   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.89   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3