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Tbio
RGS6
Regulator of G-protein signaling 6

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have bee ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355512
  • ENSP00000347699
  • ENSG00000182732
  • ENST00000404301
  • ENSP00000385243
  • ENST00000406236
  • ENSP00000384218
  • ENST00000407322
  • ENSP00000384612
  • ENST00000553525
  • ENSP00000451030
  • ENST00000553530
  • ENSP00000452331
  • ENST00000554474
  • ENSP00000450858
  • ENST00000554782
  • ENSP00000451912
  • ENST00000555571
  • ENSP00000450936
  • ENST00000556437
  • ENSP00000451855

Symbol
  • GAP
  • S914
  • HA117
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.73
transcription factor
0.73
microRNA
0.7
cell type or tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.54   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.54   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0