Tbio NUMB Protein numb homolog

Protein Summary

Description

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P49757
• B1P2N5
• B1P2N6
• B1P2N7
• B1P2N8
• B1P2N9
• B4E2B1
• Q6NUQ7
• Q86SY1
• Q8WW73
• Q9UBG1
• Q9UEQ4
• Q9UKE8
• Q9UKE9
• Q9UKF0
• Q9UQJ4
• h-Numb

Gene Name

• NUMB

Ensembl ID

• ENST00000355058
• ENSP00000347169
• ENSG00000133961
• ENST00000356296
• ENSP00000348644
• ENST00000359560
• ENSP00000352563
• ENST00000535282
• ENSP00000441258
• ENST00000544991
• ENSP00000446001
• ENST00000554521
• ENSP00000450817
• ENST00000554546
• ENSP00000452416
• ENST00000555238
• ENSP00000451300
• ENST00000555394
• ENSP00000451625
• ENST00000555738
• ENSP00000452069
• ENST00000557597
• ENSP00000451117
• ENST00000559312
• ENSP00000452888
• ENST00000560335
• ENSP00000453209

Symbol

• C14orf41
• S171
• C14orf41
• c14_5527

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.99
transcription factor perturbation	0.84
cellular component	0.78
disease perturbation	0.74
biological process	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Numb Homolog

DTO Classes

Protein / Signaling / Protein Numb Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.23   (req: < 5)

Gene RIFs: 108   (req: <= 3)

Antibodies: 743   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.23   (req: >= 5)

Gene RIFs: 108   (req: > 3)

Antibodies: 743   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0