Tbio RBM25 RNA-binding protein 25

Protein Summary

Description

RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.

Uniprot Accession IDs

• P49756
• A0PJL9
• B2RNA8
• B3KT03
• Q2TA72
• Q5XJ17
• Q6P665
• Q9H6A1
• Q9UEQ5
• Q9UIE9

Gene Name

• RBM25

Ensembl ID

• ENST00000261973
• ENSP00000261973
• ENSG00000119707
• ENST00000525321
• ENSP00000436868
• ENST00000526754
• ENSP00000436225
• ENST00000527432
• ENSP00000431150
• ENST00000528081
• ENSP00000434444

Symbol

• RNPC7
• S164
• NET52
• RNPC7
• Snu71
• RED120
• fSAP94

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
transcription factor binding site profile	0.91
histone modification site profile	0.83
microRNA	0.81
hub protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.15   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.15   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0