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Tbio
TMED10
Transmembrane emp24 domain-containing protein 10

Protein Summary
Description
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303575
  • ENSP00000303145
  • ENSG00000170348

Symbol
  • TMP21
  • p23
  • TMP21
  • p24d1
  • S31I125
  • Tmp-21-I
  • S31III125
  • P24(DELTA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
virus perturbation
0.99
transcription factor binding site profile
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.07   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.07   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
79.7
1
1
0
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
79.7
0
1
13.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane p24 trafficking protein 10
701522
Mouse
MGI:1915831
68581
Rat
RGD:620970
84599
Dog
transmembrane p24 trafficking protein 10
VGNC:47437
610559
Horse
transmembrane p24 trafficking protein 10
VGNC:24168
100051561
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane p24 trafficking protein 10
Mouse
Rat
Dog
transmembrane p24 trafficking protein 10
Horse
transmembrane p24 trafficking protein 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49755-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cargo concentration in the ER
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (276)
1 – 10 of 276
TMED4
Tdark
Novelty: 0.22372593
p_int: 0.999731581
p_ni: 0.000268419
Score: 0.994
Data Source: BioPlex,STRINGDB
GOLGB1
Tbio
Novelty: 0.00943584
p_int: 0.99966241
p_ni: 0.00033759
Score: 0.925
Data Source: BioPlex,STRINGDB
LIPG
Tchem
Family: Enzyme
Novelty: 0.00412129
p_int: 0.982460412
p_ni: 0.017539588
Score: 0.667
Data Source: BioPlex,STRINGDB
TMED7
Tdark
Novelty: 0.31193294
p_int: 0.972166143
p_ni: 0.027833627
p_wrong: 2.3e-7
Score: 0.966
Data Source: BioPlex,STRINGDB
TMED1
Tbio
Novelty: 0.11862267
p_int: 0.970868384
p_ni: 0.029131616
Score: 0.941
Data Source: BioPlex,STRINGDB
TMED3
Tbio
Novelty: 0.06696993
p_int: 0.965514524
p_ni: 0.034485476
Score: 0.993
Data Source: BioPlex,STRINGDB
FGF3
Tbio
Novelty: 0.00474087
p_int: 0.766821967
p_ni: 0.233178033
Score: 0.435
Data Source: BioPlex,STRINGDB
TMED9
Tdark
Novelty: 0.24024246
Score: 0.999
Data Source: Reactome,STRINGDB
TMED2
Tbio
Novelty: 0.03731104
Score: 0.999
Data Source: Reactome,STRINGDB
SEC22B
Tbio
Novelty: 0.03035448
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.07

PubMed score by year
PubTator Score  30.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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