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Tbio
VPS41
Vacuolar protein sorting-associated protein 41 homolog

Protein Classes
Protein Summary
Description
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). May link the HOPS complex to endosomal Ra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310301
  • ENSP00000309457
  • ENSG00000006715
  • ENST00000395969
  • ENSP00000379297

Symbol
  • HVPS41
  • HVSP41
  • hVps41p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.99
kinase perturbation
0.95
protein domain
0.92
transcription factor perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
3
1
5.8
88.4
wellbeing measurement
4
2
4
88.2
depressive symptom measurement
1
1
1
72.9
unipolar depression
1
1
0
5.7
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
5.8
88.4
wellbeing measurement
4
88.2
depressive symptom measurement
1
72.9
unipolar depression
0
5.7
57.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS41, HOPS complex subunit
VGNC:8787
463365
Macaque
VPS41, HOPS complex subunit
712457
Mouse
MGI:1929215
218035
Rat
RGD:1560511
306991
Dog
VPS41, HOPS complex subunit
VGNC:48291
475876
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS41, HOPS complex subunit
Macaque
VPS41, HOPS complex subunit
Mouse
Rat
Dog
VPS41, HOPS complex subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49754-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
T-Cell antigen Receptor (TCR) Signaling Pathway
WikiPathways
Chromosomal and microsatellite instability in colorectal cancer
Name
Explore in Pharos
Explore in Source
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
T-Cell antigen Receptor (TCR) Signaling Pathway
Chromosomal and microsatellite instability in colorectal cancer
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (115)
1 – 10 of 115
TECPR2
Tbio
Novelty: 0.11606334
p_int: 0.999999934
p_ni: 5.5e-8
p_wrong: 1.1e-8
Score: 0.86
Data Source: BioPlex,STRINGDB
VPS18
Tbio
Novelty: 0.00726539
p_int: 0.999999817
p_ni: 1.83e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TGFBRAP1
Tbio
Novelty: 0.05996919
p_int: 0.999999056
p_ni: 9.44e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
VPS11
Tbio
Novelty: 0.00496411
p_int: 0.999997882
p_ni: 0.000002118
Score: 0.999
Data Source: BioPlex,STRINGDB
CT55
Tdark
Novelty: 0.20854606
p_int: 0.999997406
p_ni: 0.000002168
p_wrong: 4.27e-7
Score: 0.848
Data Source: BioPlex,STRINGDB
VPS16
Tbio
Novelty: 0.03575558
p_int: 0.999994499
p_ni: 0.000005501
Score: 0.999
Data Source: BioPlex,STRINGDB
VPS33A
Tbio
Novelty: 0.08316241
p_int: 0.99993487
p_ni: 0.00006513
Score: 0.999
Data Source: BioPlex,STRINGDB
BICD2
Tbio
Novelty: 0.01725046
p_int: 0.999253245
p_ni: 0.000134374
p_wrong: 0.000612381
Data Source: BioPlex
VPS39
Tbio
Novelty: 0.02172601
Score: 0.997
Data Source: STRINGDB
VPS8
Tbio
Novelty: 0.05178496
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.17

PubMed score by year
PubTator Score  21.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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