Tdark YLPM1 YLP motif-containing protein 1

Protein Summary

Description

Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.

Uniprot Accession IDs

• P49750
• P49752
• Q96I64
• Q9P1V7

Gene Name

• YLPM1

Ensembl ID

• ENST00000325680
• ENSP00000324463
• ENSG00000119596

Symbol

• C14orf170
• ZAP3
• ZAP3
• ZAP113
• PPP1R169
• C14orf170

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
interacting protein	0.96
virus perturbation	0.94
transcription factor binding site profile	0.77
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Ylp Motif-containing Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Ylp Motif-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.89   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.89   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0