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Tbio
COMP
Cartilage oligomeric matrix protein

Protein Summary
Description
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombosp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222271
  • ENSP00000222271
  • ENSG00000105664
  • ENST00000425807
  • ENSP00000403792

Symbol
  • MED
  • EDM1
  • EPD1
  • TSP5
  • PSACH
  • THBS5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.83
molecular function
0.76
biological term
0.73
small molecule perturbation
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.48   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.48   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
3
6
90.4
body height
1
1
1
71.2
growth differentiation factor 15 measurement
1
1
1
67.8
visceral adipose tissue measurement
1
1
1
59.8
3
3
1
1.1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
90.4
body height
1
71.2
growth differentiation factor 15 measurement
1
67.8
visceral adipose tissue measurement
1
59.8
1
1.1
57.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cartilage oligomeric matrix protein
VGNC:2382
469068
Macaque
cartilage oligomeric matrix protein
720286
Mouse
MGI:88469
12845
Rat
RGD:2378
25304
Dog
cartilage oligomeric matrix protein
VGNC:39500
476665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cartilage oligomeric matrix protein
Macaque
cartilage oligomeric matrix protein
Mouse
Rat
Dog
cartilage oligomeric matrix protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Integrin cell surface interactions
Gene Ontology Terms (44)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (101)
1 – 10 of 101
MATN2
Tbio
Novelty:  0.08506252
p_int:  0.999989256
p_ni:  0.000010744
Score:  0.599
Data Source:  BioPlex,STRINGDB
MATN3
Tbio
Novelty:  0.00426202
Score:  0.983
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.981
Data Source:  STRINGDB
MATN1
Tbio
Novelty:  0.00337153
Score:  0.969
Data Source:  STRINGDB
MATN4
Tdark
Novelty:  0.31964843
Score:  0.966
Data Source:  STRINGDB
CD47
Tchem
Novelty:  0.00129086
Score:  0.932
Data Source:  Reactome,STRINGDB
ITGA5
Tbio
Novelty:  0.00285802
Score:  0.92
Data Source:  Reactome,STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.917
Data Source:  Reactome,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.914
Data Source:  Reactome,STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.909
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  639.48

PubMed score by year
PubTator Score  278.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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