Protein Summary
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
- ENST00000368378
- ENSP00000357362
- ENSG00000169231
- ENST00000457183
- ENSP00000392207
- TSP3
- TSP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
histone modification site profile | 0.75 | ||
transcription factor binding site profile | 0.68 | ||
transcription factor | 0.66 | ||
tissue sample | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.04 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 180 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.04 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 180 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (97)
THBS1
Novelty: 0.00073905
p_int: 0.999998576
p_ni: 4.9e-8
p_wrong: 0.000001376
Score: 0.238
Data Source: BioPlex,STRINGDB
THBS4
Novelty: 0.00988079
p_int: 0.999975769
p_wrong: 0.000024231
Score: 0.24
Data Source: BioPlex,STRINGDB
DDX11
Family: Enzyme
Novelty: 0.02282234
p_int: 0.999929427
p_ni: 0.000070573
Data Source: BioPlex
FANCB
Novelty: 0.00268111
p_int: 0.999869827
p_ni: 0.000112551
p_wrong: 0.000017622
Score: 0.186
Data Source: BioPlex,STRINGDB
PDE7A
Family: Enzyme
Novelty: 0.00872596
p_int: 0.999783802
p_ni: 0.000216191
p_wrong: 7e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
CORO7
Novelty: 0.14307384
p_int: 0.999783802
p_ni: 0.000216191
p_wrong: 7e-9
Data Source: BioPlex
IQSEC2
Novelty: 0.01878611
p_int: 0.999354666
p_ni: 0.000192214
p_wrong: 0.00045312
Score: 0.208
Data Source: BioPlex,STRINGDB
C5orf34
Novelty: 1.01063928
p_int: 0.997516702
p_ni: 0.002480588
p_wrong: 0.00000271
Score: 0.183
Data Source: BioPlex,STRINGDB
SH3BP4
Novelty: 0.13130398
p_int: 0.996557598
p_ni: 0.003163873
p_wrong: 0.000278529
Data Source: BioPlex
BLVRA
Family: Enzyme
Novelty: 0.00526407
p_int: 0.996393393
p_ni: 0.003606607
Score: 0.229
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (3)
KEGG (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by PDGF | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Signal Transduction | ||||
Signaling by PDGF | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (52)
Items per page:
1 – 5 of 52
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 6 | 5 | 9 | 98.3 | |||||
serum gamma-glutamyl transferase measurement | 3 | 4 | 3 | 3.7 | 98 | ||||
serum urea measurement | 2 | 3 | 3 | 95.4 | |||||
reticulocyte measurement | 3 | 2 | 4 | 93.8 | |||||
cancer antigen 15.3 measurement | 1 | 2 | 2 | 93.8 | |||||
Items per page:
1 – 5 of 52
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 9 | 98.3 | |||||
serum gamma-glutamyl transferase measurement | 3 | 3.7 | 98 | ||||
serum urea measurement | 3 | 95.4 | |||||
reticulocyte measurement | 4 | 93.8 | |||||
cancer antigen 15.3 measurement | 2 | 93.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | thrombospondin 3 | VGNC:1671 | 457359 | |||||
Macaque | thrombospondin 3 | 717572 | ||||||
Mouse | MGI:98739 | 21827 | ||||||
Dog | thrombospondin 3 | VGNC:47337 | 610359 | |||||
Horse | thrombospondin 3 | VGNC:24074 | 100063449 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | thrombospondin 3 | |||||
Macaque | thrombospondin 3 | |||||
Mouse | ||||||
Dog | thrombospondin 3 | |||||
Horse | thrombospondin 3 | |||||
Publication Statistics
PubMed Score 54.04
PubMed score by year
PubTator Score 23.83
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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