Tbio THBS3 Thrombospondin-3

Protein Summary

Description

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P49746
• B1AVR8
• B4DQ20
• Q8WV34

Gene Name

• THBS3

Ensembl ID

• ENST00000368378
• ENSP00000357362
• ENSG00000169231
• ENST00000457183
• ENSP00000392207

Symbol

• TSP3
• TSP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
histone modification site profile	0.75
transcription factor binding site profile	0.68
transcription factor	0.66
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.04   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.04   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (97)

Explore Interacting Targets

1 – 10 of 97

• See Interactions on String-DB

THBS1

Tchem

Novelty:  0.00073905

p_int:  0.999998576

p_ni:  4.9e-8

p_wrong:  0.000001376

Score:  0.238

Data Source:  BioPlex,STRINGDB

THBS4

Tbio

Novelty:  0.00988079

p_int:  0.999975769

p_wrong:  0.000024231

Score:  0.24

Data Source:  BioPlex,STRINGDB

DDX11

Tbio

Family:  Enzyme

Novelty:  0.02282234

p_int:  0.999929427

p_ni:  0.000070573

Data Source:  BioPlex

FANCB

Tbio

Novelty:  0.00268111

p_int:  0.999869827

p_ni:  0.000112551

p_wrong:  0.000017622

Score:  0.186

Data Source:  BioPlex,STRINGDB

PDE7A

Tclin

Family:  Enzyme

Novelty:  0.00872596

p_int:  0.999783802

p_ni:  0.000216191

p_wrong:  7e-9

Score:  0.184

Data Source:  BioPlex,STRINGDB

CORO7

Tbio

Novelty:  0.14307384

p_int:  0.999783802

p_ni:  0.000216191

p_wrong:  7e-9

Data Source:  BioPlex

IQSEC2

Tbio

Novelty:  0.01878611

p_int:  0.999354666

p_ni:  0.000192214

p_wrong:  0.00045312

Score:  0.208

Data Source:  BioPlex,STRINGDB

C5orf34

Tdark

Novelty:  1.01063928

p_int:  0.997516702

p_ni:  0.002480588

p_wrong:  0.00000271

Score:  0.183

Data Source:  BioPlex,STRINGDB

SH3BP4

Tbio

Novelty:  0.13130398

p_int:  0.996557598

p_ni:  0.003163873

p_wrong:  0.000278529

Data Source:  BioPlex

BLVRA

Tbio

Family:  Enzyme

Novelty:  0.00526407

p_int:  0.996393393

p_ni:  0.003606607

Score:  0.229

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (3)

KEGG (6)

WikiPathways (4)

Signal Transduction (R-HSA-162582)

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Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by PDGF	53 targets	R-HSA-186797
Reactome	Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Name	Explore in Pharos	Explore in Source
Signal Transduction	2704 targets	R-HSA-162582
Signaling by PDGF	53 targets	R-HSA-186797
Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (4)

Processes (4)

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1 – 3 of 3

GO Term	Evidence	Assigned by
heparin binding	Inferred from Direct Assay (IDA)	MGI
extracellular matrix structural constituent	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
calcium ion binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (52)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 52

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	6	5	9		98.3
serum gamma-glutamyl transferase measurement	EFO_0004532	3	4	3	3.7	98
serum urea measurement	EFO_0009795	2	3	3		95.4
reticulocyte measurement	EFO_0010700	3	2	4		93.8
cancer antigen 15.3 measurement	EFO_0010585	1	2	2		93.8

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Items per page:

5

1 – 5 of 52

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	9		98.3
serum gamma-glutamyl transferase measurement	EFO_0004532	3	3.7	98
serum urea measurement	EFO_0009795	3		95.4
reticulocyte measurement	EFO_0010700	4		93.8
cancer antigen 15.3 measurement	EFO_0010585	2		93.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
1,5 anhydroglucitol measurement
age at onset
albuminuria
allergy
appendicular lean mass
aspartate aminotransferase measurement
biological sex
blood urea nitrogen measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
limbs/digits/tail phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thrombospondin 3	VGNC:1671	457359
Macaque	thrombospondin 3		717572
Mouse	thrombospondin 3	MGI:98739	21827
Dog	thrombospondin 3	VGNC:47337	610359
Horse	thrombospondin 3	VGNC:24074	100063449

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thrombospondin 3
Macaque	thrombospondin 3
Mouse	thrombospondin 3
Dog	thrombospondin 3
Horse	thrombospondin 3

Publication Statistics

PubMed Score 54.04

PubMed score by year

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PubTator Score 23.83

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (3)

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PMID	Year	Title