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Tbio
PSMB3
Proteasome subunit beta type-3

Protein Summary
Description
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619426
  • ENSP00000483688
  • ENSG00000277791
  • ENST00000619951
  • ENSP00000483956
  • ENSG00000275903

Symbol
  • HC10-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
biological process
0.98
interacting protein
0.94
transcription factor binding site profile
0.93
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (334)
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMA8
Tdark
Family:  Enzyme
Novelty:  0.83041547
p_int:  0.999999937
p_ni:  6.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.999999831
p_ni:  1.69e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSME2
Tbio
Novelty:  0.02624268
p_int:  0.999999826
p_ni:  1.74e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
POMP
Tbio
Novelty:  0.01885028
p_int:  0.999999803
p_ni:  1.97e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
p_int:  0.99999925
p_ni:  7.5e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
AKIRIN2
Tbio
Novelty:  0.04603317
p_int:  0.999998589
p_ni:  0.000001408
p_wrong:  3e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
PSME1
Tbio
Novelty:  0.01258149
p_int:  0.999997801
p_ni:  0.000002199
Score:  0.985
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.999997017
p_ni:  0.000002983
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
p_int:  0.999995992
p_ni:  0.000004008
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (155)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.4
FEV/FEC ratio
1
1
1
78.4
body height
2
1
2
68
body height
2
1
2
68
heel bone mineral density
2
1
2
52.4
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.4
FEV/FEC ratio
1
78.4
body height
2
68
body height
2
68
heel bone mineral density
2
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
proteasome subunit beta 3
694318
Mouse
MGI:1347014
26446
Rat
RGD:61875
29676
Dog
proteasome subunit beta 3
480537
Horse
proteasome subunit beta 3
VGNC:21942
100068477
Species
Name
OMA
EggNOG
Inparanoid
Macaque
proteasome subunit beta 3
Mouse
Rat
Dog
proteasome subunit beta 3
Horse
proteasome subunit beta 3
Publication Statistics
PubMed Score 6.22
PubMed score by year
PubTator Score 4.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title