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Tbio
CEBPA
CCAAT/enhancer-binding protein alpha

Protein Summary
Description
Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000498907
  • ENSP00000427514
  • ENSG00000245848

Symbol
  • CEBP
  • CEBP
  • C/EBP-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.99
virus
0.98
PubMedID
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 930.65   (req: < 5)
Gene RIFs: 344   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 930.65   (req: >= 5)
Gene RIFs: 344   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of granulopoiesis
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of granulopoiesis
Transcriptional regulation of white adipocyte differentiation
Gene Ontology Terms (56)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (295)
1 – 10 of 295
CCDC183
Tdark
p_int: 0.994543183
p_ni: 1e-9
p_wrong: 0.005456816
Score: 0.351
Data Source: BioPlex,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00013623
Score: 0.982
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00012454
Score: 0.981
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.00847283
Score: 0.98
Data Source: STRINGDB
ADIPOQ
Tbio
Novelty: 0.00013138
Score: 0.977
Data Source: STRINGDB
KLF5
Tbio
Family: TF
Novelty: 0.00475849
Score: 0.976
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.972
Data Source: STRINGDB
LEP
Tbio
Novelty: 0.0000644
Score: 0.971
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00007002
Score: 0.971
Data Source: STRINGDB
FABP4
Tchem
Novelty: 0.00130496
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  930.65

PubMed score by year
PubTator Score  1320.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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