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Tbio
CTCF
Transcriptional repressor CTCF

Protein Summary
Description
Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264010
  • ENSP00000264010
  • ENSG00000102974
  • ENST00000401394
  • ENSP00000384707
  • ENST00000642819
  • ENSP00000494408
  • ENST00000644753
  • ENSP00000493495
  • ENST00000645699
  • ENSP00000495348
  • ENST00000646076
  • ENSP00000494538

Symbol
  • MRD21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.95
virus perturbation
0.92
transcription factor binding site profile
0.89
biological process
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1458.09   (req: < 5)
Gene RIFs: 200   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1458.09   (req: >= 5)
Gene RIFs: 200   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.976598752
p_ni:  0.023401248
Score:  0.932
Data Source:  BioPlex,STRINGDB
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.968747942
p_ni:  0.031252058
Score:  0.554
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.90167464
p_ni:  0.09832536
Score:  0.227
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.868678896
p_ni:  0.131321103
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.831028308
p_ni:  0.168971692
Score:  0.203
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.826399003
p_ni:  0.173600997
Score:  0.674
Data Source:  BioPlex,STRINGDB
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.826216423
p_ni:  0.173783577
Score:  0.209
Data Source:  BioPlex,STRINGDB
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.769237058
p_ni:  0.230762942
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.765260824
p_ni:  0.234739176
Score:  0.157
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.757916501
p_ni:  0.242083499
Score:  0.264
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
3
3
92.7
lymphocyte count
2
2
3
89.2
apolipoprotein A 1 measurement
1
2
2
88.7
heel bone mineral density
2
1
2
80.4
sleep duration
1
1
1
79.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
92.7
lymphocyte count
3
89.2
apolipoprotein A 1 measurement
2
88.7
heel bone mineral density
2
80.4
sleep duration
1
79.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCCTC-binding factor
VGNC:9044
454169
Macaque
CCCTC-binding factor [Source:HGNC Symbol;Acc:HGNC:13723]
Mouse
MGI:109447
13018
Rat
RGD:621344
83726
Dog
CCCTC-binding factor
VGNC:39690
479684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCCTC-binding factor
Macaque
CCCTC-binding factor [Source:HGNC Symbol;Acc:HGNC:13723]
Mouse
Rat
Dog
CCCTC-binding factor
Publication Statistics
PubMed Score 1458.09
PubMed score by year
PubTator Score 708.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title