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Tchem
CXCR3
C-X-C chemokine receptor type 3

Protein Summary
Description
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11. This gene encodes a G protein-coupled receptor with selectivity for three chemokines ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373691
  • ENSP00000362795
  • ENSG00000186810
  • ENST00000373693
  • ENSP00000362797

Symbol
  • GPR9
  • GPR9
  • MigR
  • CD182
  • CD183
  • Mig-R
  • CKR-L2
  • CMKAR3
  • IP10-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
biological term
0.98
gene perturbation
0.69
cell type or tissue
0.68
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1152.13   (req: < 5)
Gene RIFs: 219   (req: <= 3)
Antibodies: 966   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1152.13   (req: >= 5)
Gene RIFs: 219   (req: > 3)
Antibodies: 966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 739
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0