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Tchem
CXCR3
C-X-C chemokine receptor type 3

Protein Summary
Description
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11. This gene encodes a G protein-coupled receptor with selectivity for three chemokines ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373691
  • ENSP00000362795
  • ENSG00000186810
  • ENST00000373693
  • ENSP00000362797

Symbol
  • GPR9
  • GPR9
  • MigR
  • CD182
  • CD183
  • Mig-R
  • CKR-L2
  • CMKAR3
  • IP10-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
biological term
0.98
gene perturbation
0.69
cell type or tissue
0.68
molecular function
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1001.52   (req: < 5)
Gene RIFs: 219   (req: <= 3)
Antibodies: 966   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1001.52   (req: >= 5)
Gene RIFs: 219   (req: > 3)
Antibodies: 966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 357
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
0.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-X-C motif chemokine receptor 3
699438
Mouse
MGI:1277207
12766
Rat
RGD:621528
84475
Dog
C-X-C motif chemokine receptor 3
VGNC:39750
491952
Horse
C-X-C motif chemokine receptor 3
VGNC:16986
100056190
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-X-C motif chemokine receptor 3
Mouse
Rat
Dog
C-X-C motif chemokine receptor 3
Horse
C-X-C motif chemokine receptor 3
Pathways (18)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (36)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (419)
1 – 10 of 419
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.997
Data Source: Reactome,STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.996
Data Source: Reactome,STRINGDB
CXCL11
Tbio
Novelty: 0.00077765
Score: 0.995
Data Source: Reactome,STRINGDB
PF4
Tbio
Novelty: 0.00038481
Score: 0.984
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.983
Data Source: STRINGDB
CXCL13
Tbio
Novelty: 0.00118688
Score: 0.977
Data Source: STRINGDB
CCL11
Tbio
Novelty: 0.00086805
Score: 0.975
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.974
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.972
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  1001.52

PubMed score by year
PubTator Score  615.9

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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