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Tbio
STAR
Steroidogenic acute regulatory protein, mitochondrial

Protein Summary
Description
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276449
  • ENSP00000276449
  • ENSG00000147465

Symbol
  • STARD1
  • STARD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.98
gene perturbation
0.83
biological term
0.75
disease perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 822.82   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 822.82   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
steroidogenic acute regulatory protein
VGNC:788
746738
Macaque
steroidogenic acute regulatory protein
699515
Mouse
MGI:102760
20845
Rat
RGD:3770
25557
Dog
steroidogenic acute regulatory protein
VGNC:46880
475588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
steroidogenic acute regulatory protein
Macaque
steroidogenic acute regulatory protein
Mouse
Rat
Dog
steroidogenic acute regulatory protein
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49675-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Reactome
Pregnenolone biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Pregnenolone biosynthesis
Gene Ontology Terms (59)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (105)
1 – 10 of 105
CYP11A1
Tclin
Family: Enzyme
Novelty: 0.00096368
Score: 0.994
Data Source: STRINGDB
FDX1
Tbio
Novelty: 0.00124491
Score: 0.97
Data Source: STRINGDB
STARD3NL
Tbio
Novelty: 0.11798896
Score: 0.969
Data Source: Reactome,STRINGDB
FDXR
Tbio
Family: Enzyme
Novelty: 0.00171588
Score: 0.951
Data Source: STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.927
Data Source: STRINGDB
STARD4
Tbio
Novelty: 0.05932371
Score: 0.926
Data Source: STRINGDB
VDAC2
Tchem
Novelty: 0.00575936
Score: 0.923
Data Source: STRINGDB
STARD6
Tbio
Novelty: 0.08085975
Score: 0.92
Data Source: STRINGDB
STARD3
Tbio
Novelty: 0.01540936
Score: 0.913
Data Source: Reactome,STRINGDB
FDX2
Tdark
Novelty: 0.05747769
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  822.82

PubMed score by year
PubTator Score  907.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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