Tclin CSNK1E Casein kinase I isoform epsilon

Protein Summary

Description

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• P49674
• CKI-epsilon

Gene Name

• CSNK1E

Ensembl ID

• ENST00000359867
• ENSP00000352929
• ENSG00000213923
• ENST00000396832
• ENSP00000380044
• ENST00000403904
• ENSP00000384074

Symbol

• LOC400927-CSNK1E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
kinase perturbation	0.99
transcription factor perturbation	0.88
small molecule	0.85
PubMedID	0.8

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Casein Kinase I Isoform Epsilon

DTO Classes

Protein / Kinase / Protein Kinase / Ck1 Group / Ck1 Family / Casein Kinase I Isoform Epsilon

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.61   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 437   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.61   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 229

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (2)

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1 – 2 of 2

sunitinib

CSNK1ETclin Kinase

INHIBITOR pIC50 : 6.96

umbralisib

CSNK1ETclin Kinase

INHIBITOR pKd : 6.74

Active Ligands (229)

Explore Active Ligands

1 – 10 of 229

PF-670462

CSNK1ETclin Kinase

pIC50 : 8.11

IC261

CSNK1ETclin Kinase

pIC50 : 6

CHEMBL2420704

CSNK1ETclin Kinase

pIC50 : 8.18

PF-4800567

CSNK1ETclin Kinase

pIC50 : 7.49

US9475817, 117

CSNK1ETclin Kinase

pIC50 : 10

US9475817, 123

CSNK1ETclin Kinase

pIC50 : 10

US9475817, 124

CSNK1ETclin Kinase

pIC50 : 9.7

US9475817, 158

CSNK1ETclin Kinase

pIC50 : 9.7

US9475817, 178

CSNK1ETclin Kinase

pIC50 : 9.7

US9475817, 196

CSNK1ETclin Kinase

pIC50 : 9.7

Protein-Protein Interactions (366)

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1 – 10 of 366

• See Interactions on String-DB

SNX24

Tdark

Novelty:  0.20838126

p_int:  0.999999983

p_ni:  1.7e-8

Score:  0.226

Data Source:  BioPlex,STRINGDB

CSNK1D

Tchem

Family:  Kinase

Novelty:  0.00896935

p_int:  0.999999823

p_ni:  1.73e-7

p_wrong:  3e-9

Score:  0.981

Data Source:  BioPlex,STRINGDB

CRY1

Tchem

Novelty:  0.00116593

p_int:  0.999999606

p_ni:  3.94e-7

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

ZNF618

Tdark

Novelty:  0.43589506

p_int:  0.999999193

p_ni:  8.05e-7

p_wrong:  3e-9

Score:  0.563

Data Source:  BioPlex,STRINGDB

GAPVD1

Tbio

Family:  Enzyme

Novelty:  0.13142098

p_int:  0.999997442

p_ni:  0.000002558

Score:  0.654

Data Source:  BioPlex,STRINGDB

PER2

Tchem

Novelty:  0.00165834

p_int:  0.999997194

p_ni:  9.73e-7

p_wrong:  0.000001833

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

FAM110B

Tbio

Novelty:  0.35516609

p_int:  0.999994712

p_ni:  5.1e-7

p_wrong:  0.000004778

Score:  0.726

Data Source:  BioPlex,STRINGDB

PDE4DIP

Tbio

Novelty:  0.03414104

p_int:  0.999870383

p_ni:  0.000129617

Score:  0.153

Data Source:  BioPlex,STRINGDB

DBNDD1

Tdark

Novelty:  0.60202124

p_int:  0.999835089

p_ni:  0.000164911

Data Source:  BioPlex

PER1

Tbio

Novelty:  0.01290576

p_int:  0.999822687

p_ni:  0.000177311

p_wrong:  2e-9

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Downstream (3)

1 – 3 of 3

S1PR1

Tclin

Family:  GPCR

KEGG Distance:  2

Common Pathways:  1

1: FoxO signaling pathway

S1PR4

Tclin

Family:  GPCR

KEGG Distance:  2

Common Pathways:  1

1: FoxO signaling pathway

ITGB2

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  1

1: Hippo signaling pathway

Pathways (71)

Reactome (25)

KEGG (6)

PathwayCommons (22)

WikiPathways (18)

AURKA Activation by TPX2 (R-HSA-8854518)

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Items per page:

5

1 – 5 of 25

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (4)

Components (4)

Processes (18)

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1 – 4 of 4

GO Term	Evidence	Assigned by
protein kinase activity	Inferred from Direct Assay (IDA)	WormBase
protein serine/threonine kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (18)

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1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	4	5	4	6.3	93.2
triglyceride measurement	EFO_0004530	6	4	6		92.7
serum alanine aminotransferase measurement	EFO_0004735	2	2	1	6.9	80
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		67.1
body fat percentage	EFO_0007800	2	2	3		66.6

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5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	4	6.3	93.2
triglyceride measurement	EFO_0004530	6		92.7
serum alanine aminotransferase measurement	EFO_0004735	1	6.9	80
high density lipoprotein cholesterol measurement	EFO_0004612	1		67.1
body fat percentage	EFO_0007800	3		66.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Biological rhythms
Complete proteome
Cytoplasm
Kinase
Methylation
Nucleotide-binding
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
birth weight
BMI-adjusted waist circumference
body fat percentage
body height
dense area measurement
glomerular filtration rate
hemoglobin measurement
high density lipoprotein cholesterol measurement
mammographic density measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	casein kinase 1 epsilon	VGNC:7338	458829
Macaque	casein kinase 1, epsilon		700565
Mouse	casein kinase 1, epsilon	MGI:1351660	27373
Rat	casein kinase 1, epsilon	RGD:62045	58822
Dog	casein kinase 1 epsilon	VGNC:54522	474510

Species	Name	OMA	EggNOG	Inparanoid
Chimp	casein kinase 1 epsilon
Macaque	casein kinase 1, epsilon
Mouse	casein kinase 1, epsilon
Rat	casein kinase 1, epsilon
Dog	casein kinase 1 epsilon

Publication Statistics

PubMed Score 104.61

PubMed score by year

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PubTator Score 13.96

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Related Publications

Text Mined References (42)

GeneRif Annotations (1)

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PMID	Year	Title