CSNK1E
Casein kinase I isoform epsilon
Protein Classes
Protein Summary
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]
- ENST00000359867
- ENSP00000352929
- ENSG00000213923
- ENST00000396832
- ENSP00000380044
- ENST00000403904
- ENSP00000384074
- LOC400927-CSNK1E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.99 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.88 | ||
small molecule | 0.85 | ||
PubMedID | 0.8 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.11 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 437 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.11 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 437 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 217
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (217)
1 – 10 of 217
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (71)
Reactome (25)
KEGG (6)
PathwayCommons (22)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 25
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Centrosome maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Centrosome maturation | ||||
Gene Ontology Terms (26)
Functions (4)
Components (4)
Processes (18)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (366)
1 – 10 of 366
SNX24
Novelty: 0.20838126
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.226
Data Source: BioPlex,STRINGDB
CSNK1D
Family: Kinase
Novelty: 0.00896935
p_int: 0.999999823
p_ni: 1.73e-7
p_wrong: 3e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
CRY1
Novelty: 0.00116593
p_int: 0.999999606
p_ni: 3.94e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ZNF618
Novelty: 0.43589506
p_int: 0.999999193
p_ni: 8.05e-7
p_wrong: 3e-9
Score: 0.563
Data Source: BioPlex,STRINGDB
GAPVD1
Family: Enzyme
Novelty: 0.13142098
p_int: 0.999997442
p_ni: 0.000002558
Score: 0.654
Data Source: BioPlex,STRINGDB
PER2
Novelty: 0.00165834
p_int: 0.999997194
p_ni: 9.73e-7
p_wrong: 0.000001833
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
FAM110B
Novelty: 0.35516609
p_int: 0.999994712
p_ni: 5.1e-7
p_wrong: 0.000004778
Score: 0.726
Data Source: BioPlex,STRINGDB
PDE4DIP
Novelty: 0.03414104
p_int: 0.999870383
p_ni: 0.000129617
Score: 0.153
Data Source: BioPlex,STRINGDB
DBNDD1
Novelty: 0.60202124
p_int: 0.999835089
p_ni: 0.000164911
Data Source: BioPlex
PER1
Novelty: 0.01290576
p_int: 0.999822687
p_ni: 0.000177311
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score 101.11
PubMed score by year
PubTator Score 13.96
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
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