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Tclin
CSNK1E
Casein kinase I isoform epsilon

Protein Summary
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359867
  • ENSP00000352929
  • ENSG00000213923
  • ENST00000396832
  • ENSP00000380044
  • ENST00000403904
  • ENSP00000384074

Symbol
  • LOC400927-CSNK1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
kinase perturbation
0.99
transcription factor perturbation
0.88
small molecule
0.85
PubMedID
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.61   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 437   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.61   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 229
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (366)
SNX24
Tdark
Novelty:  0.20838126
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.226
Data Source:  BioPlex,STRINGDB
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.999999823
p_ni:  1.73e-7
p_wrong:  3e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
CRY1
Tchem
Novelty:  0.00116593
p_int:  0.999999606
p_ni:  3.94e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ZNF618
Tdark
Novelty:  0.43589506
p_int:  0.999999193
p_ni:  8.05e-7
p_wrong:  3e-9
Score:  0.563
Data Source:  BioPlex,STRINGDB
GAPVD1
Tbio
Family:  Enzyme
Novelty:  0.13142098
p_int:  0.999997442
p_ni:  0.000002558
Score:  0.654
Data Source:  BioPlex,STRINGDB
PER2
Tchem
Novelty:  0.00165834
p_int:  0.999997194
p_ni:  9.73e-7
p_wrong:  0.000001833
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
FAM110B
Tbio
Novelty:  0.35516609
p_int:  0.999994712
p_ni:  5.1e-7
p_wrong:  0.000004778
Score:  0.726
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999870383
p_ni:  0.000129617
Score:  0.153
Data Source:  BioPlex,STRINGDB
DBNDD1
Tdark
Novelty:  0.60202124
p_int:  0.999835089
p_ni:  0.000164911
Data Source:  BioPlex
PER1
Tbio
Novelty:  0.01290576
p_int:  0.999822687
p_ni:  0.000177311
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
Pathways (71)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
5
4
6.3
93.2
triglyceride measurement
6
4
6
92.7
serum alanine aminotransferase measurement
2
2
1
6.9
80
high density lipoprotein cholesterol measurement
1
1
1
67.1
body fat percentage
2
2
3
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
6.3
93.2
triglyceride measurement
6
92.7
serum alanine aminotransferase measurement
1
6.9
80
high density lipoprotein cholesterol measurement
1
67.1
body fat percentage
3
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
casein kinase 1 epsilon
VGNC:7338
458829
Macaque
casein kinase 1, epsilon
700565
Mouse
MGI:1351660
27373
Rat
RGD:62045
58822
Dog
casein kinase 1 epsilon
VGNC:54522
474510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
casein kinase 1 epsilon
Macaque
casein kinase 1, epsilon
Mouse
Rat
Dog
casein kinase 1 epsilon
Publication Statistics
PubMed Score 104.61
PubMed score by year
PubTator Score 13.96
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title