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Tchem
CSNK1E
Casein kinase I isoform epsilon

Protein Summary
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359867
  • ENSP00000352929
  • ENSG00000213923
  • ENST00000396832
  • ENSP00000380044
  • ENST00000403904
  • ENSP00000384074

Symbol
  • LOC400927-CSNK1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
kinase perturbation
0.99
transcription factor perturbation
0.88
small molecule
0.85
PubMedID
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 437   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 217
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
Active Ligands (217)
1 – 10 of 217
CHEMBL1951415
chemical structure image
CHEMBL3958671,CHEMBL3889723
chemical structure image
CHEMBL3913933
chemical structure image
CHEMBL3889600
chemical structure image
CHEMBL3916526,CHEMBL3948521
chemical structure image
CHEMBL3894506
chemical structure image
CHEMBL2420704
chemical structure image
CHEMBL3952882
chemical structure image
CHEMBL3948730
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (71)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (366)
1 – 10 of 366
SNX24
Tdark
Novelty: 0.20838126
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.226
Data Source: BioPlex,STRINGDB
CSNK1D
Tchem
Family: Kinase
Novelty: 0.00896935
p_int: 0.999999823
p_ni: 1.73e-7
p_wrong: 3e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
CRY1
Tchem
Novelty: 0.00116593
p_int: 0.999999606
p_ni: 3.94e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ZNF618
Tdark
Novelty: 0.43589506
p_int: 0.999999193
p_ni: 8.05e-7
p_wrong: 3e-9
Score: 0.563
Data Source: BioPlex,STRINGDB
GAPVD1
Tbio
Family: Enzyme
Novelty: 0.13142098
p_int: 0.999997442
p_ni: 0.000002558
Score: 0.654
Data Source: BioPlex,STRINGDB
PER2
Tchem
Novelty: 0.00165834
p_int: 0.999997194
p_ni: 9.73e-7
p_wrong: 0.000001833
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
FAM110B
Tbio
Novelty: 0.35516609
p_int: 0.999994712
p_ni: 5.1e-7
p_wrong: 0.000004778
Score: 0.726
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999870383
p_ni: 0.000129617
Score: 0.153
Data Source: BioPlex,STRINGDB
DBNDD1
Tdark
Novelty: 0.60202124
p_int: 0.999835089
p_ni: 0.000164911
Data Source: BioPlex
PER1
Tbio
Novelty: 0.01290576
p_int: 0.999822687
p_ni: 0.000177311
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  101.11

PubMed score by year
PubTator Score  13.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer