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Tbio
PRIM1
DNA primase small subunit

Protein Summary
Description
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338193
  • ENSP00000350491
  • ENSG00000198056

Symbol
  • p49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
virus perturbation
0.85
gene perturbation
0.81
kinase perturbation
0.81
disease perturbation
0.68


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Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.96   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.96   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
83
appendicular lean mass
3
1
3
81.3
BMI-adjusted waist-hip ratio
1
1
1
80.9
mean corpuscular hemoglobin concentration
1
1
1
78.8
1
1
1
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
83
appendicular lean mass
3
81.3
BMI-adjusted waist-hip ratio
1
80.9
mean corpuscular hemoglobin concentration
1
78.8
1
78.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA primase subunit 1
VGNC:8501
746924
Mouse
MGI:97757
19075
Rat
RGD:621380
246327
Horse
DNA primase subunit 1
100146777
Cow
DNA primase subunit 1
VGNC:49067
506240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA primase subunit 1
Mouse
Rat
Horse
DNA primase subunit 1
Cow
DNA primase subunit 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49642-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Replication
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Replication
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (273)
1 – 10 of 273
POLA2
Tbio
Family: Enzyme
Novelty: 0.07371844
p_int: 0.99999974
p_ni: 2.6e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRIM2
Tbio
Family: Enzyme
Novelty: 0.05145449
p_int: 0.999999684
p_ni: 3.16e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
POLA1
Tclin
Family: Enzyme
Novelty: 0.0039096
p_int: 0.999999195
p_ni: 8.05e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BTF3
Tbio
Novelty: 0.01198537
p_int: 0.999957544
p_ni: 0.000042456
Data Source: BioPlex
BTF3L4
Tdark
Novelty: 0.61724061
p_int: 0.999956849
p_ni: 0.000043151
Data Source: BioPlex
NLGN4Y
Tbio
Family: Enzyme
p_int: 0.999636142
p_ni: 0.000363858
Data Source: BioPlex
RNF31
Tbio
Family: Enzyme
Novelty: 0.01394304
p_int: 0.979024334
p_ni: 0.020742159
p_wrong: 0.000233507
Score: 0.338
Data Source: BioPlex,STRINGDB
DCAF10
Tdark
Novelty: 2.6713128
p_int: 0.967616666
p_ni: 0.032382641
p_wrong: 6.93e-7
Score: 0.466
Data Source: BioPlex,STRINGDB
RAE1
Tbio
Novelty: 0.01342883
p_int: 0.961365129
p_ni: 0.038634871
Score: 0.661
Data Source: BioPlex,STRINGDB
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.922957705
p_ni: 0.077042295
Score: 0.28
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.96

PubMed score by year
PubTator Score  53.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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