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Tbio
MAN2A2
Alpha-mannosidase 2x

Protein Summary
Description
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360468
  • ENSP00000353655
  • ENSG00000196547
  • ENST00000559717
  • ENSP00000452948

Symbol
  • MANA2X
  • MANA2X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.9
virus perturbation
0.9
transcription factor binding site profile
0.68
tissue sample
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 2A member 2
VGNC:7533
745986
Macaque
mannosidase alpha class 2A member 2
715720
Mouse
MGI:2150656
140481
Rat
RGD:1310238
308757
Dog
mannosidase alpha class 2A member 2
VGNC:42946
488745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosidase alpha class 2A member 2
Macaque
mannosidase alpha class 2A member 2
Mouse
Rat
Dog
mannosidase alpha class 2A member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49641-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (89)
1 – 10 of 89
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.999959051
p_ni: 0.000040949
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.999919409
p_ni: 0.000080591
Data Source: BioPlex
FUT8
Tbio
Family: Enzyme
Novelty: 0.00675388
p_int: 0.999669165
p_ni: 0.000330835
Score: 0.634
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.999125349
p_ni: 0.000874651
Data Source: BioPlex
CLEC12A
Tbio
Novelty: 0.01478908
p_int: 0.988445527
p_ni: 0.011554473
Data Source: BioPlex
SLC9A6
Tbio
Family: Transporter
Novelty: 0.01410234
p_int: 0.975242649
p_ni: 0.024757344
p_wrong: 7e-9
Data Source: BioPlex
SUSD4
Tbio
Novelty: 0.22201938
p_int: 0.974343346
p_ni: 0.025656653
p_wrong: 1e-9
Data Source: BioPlex
MCOLN2
Tchem
Family: IC
Novelty: 0.05195244
p_int: 0.967160549
p_ni: 0.032807889
p_wrong: 0.000031562
Data Source: BioPlex
HLA-DRA
Tbio
Novelty: 0.0060214
p_int: 0.963455499
p_ni: 0.0365445
Data Source: BioPlex
CD1E
Tbio
Novelty: 0.00171622
p_int: 0.939799473
p_ni: 0.060200527
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  13.22

PubMed score by year
PubTator Score  3.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer