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Tbio
DGKG
Diacylglycerol kinase gamma

Protein Classes
Protein Summary
Description
Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid. This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265022
  • ENSP00000265022
  • ENSG00000058866
  • ENST00000344484
  • ENSP00000339777
  • ENST00000382164
  • ENSP00000371599

Symbol
  • DAGK3
  • DAGK3
  • DGK-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
metabolite
0.85
microRNA
0.7
histone modification site profile
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
18
5
28
2.8
97.5
high density lipoprotein cholesterol measurement
7
7
10
94.6
glomerular filtration rate
5
5
5
93.2
intraocular pressure measurement
6
2
7
85
chronotype measurement
2
3
2
1
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
28
2.8
97.5
high density lipoprotein cholesterol measurement
10
94.6
glomerular filtration rate
5
93.2
intraocular pressure measurement
7
85
chronotype measurement
2
1
81.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase gamma
VGNC:1792
460907
Macaque
diacylglycerol kinase gamma
699967
Mouse
MGI:105060
110197
Rat
RGD:2499
25666
Dog
diacylglycerol kinase gamma
VGNC:39919
488115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase gamma
Macaque
diacylglycerol kinase gamma
Mouse
Rat
Dog
diacylglycerol kinase gamma
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49619-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (106)
1 – 10 of 106
ZC2HC1A
Tdark
Novelty:  0.75491818
p_int:  1
Data Source:  BioPlex
DGKH
Tbio
Family:  Kinase
Novelty:  0.01576406
p_int:  0.999999973
p_ni:  2.6e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
SMCHD1
Tbio
Novelty:  0.01383021
p_int:  0.99999985
p_ni:  1.5e-7
Data Source:  BioPlex
DGKD
Tbio
Family:  Enzyme
Novelty:  0.03749316
p_int:  0.999999274
p_ni:  1.5e-8
p_wrong:  7.1e-7
Score:  0.194
Data Source:  BioPlex,STRINGDB
FBXW8
Tbio
Novelty:  0.06697145
p_int:  0.999983976
p_ni:  0.000015332
p_wrong:  6.92e-7
Data Source:  BioPlex
CUL7
Tbio
Novelty:  0.02183958
p_int:  0.999904325
p_ni:  0.000095675
Data Source:  BioPlex
TBL1X
Tbio
Novelty:  0.00027212
p_int:  0.999807722
p_ni:  0.000192278
Data Source:  BioPlex
TBL1XR1
Tbio
Novelty:  0.00503043
p_int:  0.999679528
p_ni:  0.0003203
p_wrong:  1.72e-7
Data Source:  BioPlex
VCPIP1
Tbio
Novelty:  0.09915033
p_int:  0.998416018
p_ni:  0.001583981
Data Source:  BioPlex
DHTKD1
Tbio
Family:  Enzyme
Novelty:  0.0381406
p_int:  0.995749298
p_ni:  0.004250678
p_wrong:  2.4e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  30.34

PubMed score by year
PubTator Score  11.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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