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Tbio
SARS
Serine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000). This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234677
  • ENSP00000234677
  • ENSG00000031698

Symbol
  • SERS
  • SERS
  • SERRS
  • NEDMAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.98
kinase perturbation
0.93
molecular function
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.51   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.51   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
98.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
98.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
seryl-tRNA synthetase
VGNC:6991
457085
Macaque
seryl-tRNA synthetase
697810
Mouse
MGI:102809
20226
Rat
RGD:628813
266975
Dog
seryl-tRNA synthetase
VGNC:45869
490124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
seryl-tRNA synthetase
Macaque
seryl-tRNA synthetase
Mouse
Rat
Dog
seryl-tRNA synthetase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49591-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (135)
1 – 10 of 135
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.587
Data Source: BioPlex,STRINGDB
DUS3L
Tdark
Family: Enzyme
Novelty: 0.24952542
p_int: 0.999993917
p_ni: 0.000006057
p_wrong: 2.6e-8
Score: 0.417
Data Source: BioPlex,STRINGDB
R3HCC1L
Tbio
Novelty: 0.00654375
p_int: 0.995252001
p_ni: 0.000004192
p_wrong: 0.004743806
Score: 0.519
Data Source: BioPlex,STRINGDB
FRMPD2
Tbio
Novelty: 0.40302485
p_int: 0.932256511
p_ni: 0.067743489
Score: 0.519
Data Source: BioPlex,STRINGDB
C12orf45
Tdark
Novelty: 3.65358593
p_int: 0.81659947
p_ni: 0.000036203
p_wrong: 0.183364327
Score: 0.282
Data Source: BioPlex,STRINGDB
PSTK
Tbio
Family: Kinase
Novelty: 0.0280647
Score: 0.992
Data Source: STRINGDB
GARS
Tbio
Family: Enzyme
Novelty: 0.00190498
Score: 0.983
Data Source: STRINGDB
AARS
Tbio
Family: Enzyme
Novelty: 0.00203732
Score: 0.979
Data Source: STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.975
Data Source: STRINGDB
TARS
Tchem
Family: Enzyme
Novelty: 0.00795387
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.51

PubMed score by year
PubTator Score  144.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer