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Tchem
CARS
Cysteine--tRNA ligase, cytoplasmic

Protein Summary
Description
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278224
  • ENSP00000278224
  • ENSG00000110619
  • ENST00000380525
  • ENSP00000369897
  • ENST00000397111
  • ENSP00000380300
  • ENST00000612826
  • ENSP00000482336
  • ENSG00000278191
  • ENST00000632612
  • ENSP00000487923
  • ENST00000633248
  • ENSP00000488657

Symbol
  • CARS1
  • CYSRS
  • MGC:11246
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.93
transcription factor perturbation
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.09   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.09   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
1 – 2 of 2
osimertinib
Rendered image for osimertinib
icotinib
Rendered image for icotinib
Protein-Protein Interactions (297)
1 – 10 of 297
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.999988594
p_ni:  0.000011406
Score:  0.829
Data Source:  BioPlex,STRINGDB
EEF1G
Tbio
Novelty:  0.01473013
p_int:  0.99998633
p_ni:  0.00001367
Score:  0.997
Data Source:  BioPlex,STRINGDB
EEF1A1
Tchem
Novelty:  0.00059953
p_int:  0.99996164
p_ni:  0.00003836
Score:  0.942
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.99990079
p_ni:  0.00009921
Score:  0.894
Data Source:  BioPlex,STRINGDB
ABTB1
Tbio
Novelty:  0.08918942
p_int:  0.998282948
p_ni:  0.001717052
Score:  0.859
Data Source:  BioPlex,STRINGDB
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.992557929
p_ni:  0.007442071
Score:  0.804
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.895067661
p_ni:  0.104932339
Data Source:  BioPlex
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.801582034
p_ni:  0.198417966
Score:  0.323
Data Source:  BioPlex,STRINGDB
YARS
Tchem
Family:  Enzyme
Novelty:  0.00302115
Score:  0.986
Data Source:  STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
Score:  0.981
Data Source:  STRINGDB
Pathways (7)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
3
3
6
92.9
bilirubin measurement
3
3
6
92.9
apolipoprotein A 1 measurement
2
2
2
82
apolipoprotein A 1 measurement
2
2
2
82
high density lipoprotein cholesterol measurement
5
3
6
77.9
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
6
92.9
bilirubin measurement
6
92.9
apolipoprotein A 1 measurement
2
82
apolipoprotein A 1 measurement
2
82
high density lipoprotein cholesterol measurement
6
77.9
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteinyl-tRNA synthetase
VGNC:11276
450962
Macaque
cysteinyl-tRNA synthetase
706502
Mouse
MGI:1351477
27267
Rat
RGD:1310747
293638
Dog
cysteinyl-tRNA synthetase
VGNC:38726
475998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteinyl-tRNA synthetase
Macaque
cysteinyl-tRNA synthetase
Mouse
Rat
Dog
cysteinyl-tRNA synthetase
Publication Statistics
PubMed Score 46.09
PubMed score by year
PubTator Score 129.40
PubTator score by year