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Tbio
CARS
Cysteine--tRNA ligase, cytoplasmic

Protein Summary
Description
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278224
  • ENSP00000278224
  • ENSG00000110619
  • ENST00000380525
  • ENSP00000369897
  • ENST00000397111
  • ENSP00000380300
  • ENST00000612826
  • ENSP00000482336
  • ENSG00000278191
  • ENST00000632612
  • ENSP00000487923
  • ENST00000633248
  • ENSP00000488657

Symbol
  • CARS1
  • CYSRS
  • MGC:11246
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.93
transcription factor perturbation
0.91
kinase perturbation
0.84
transcription factor binding site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.86   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.86   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
1
1
57.7
calcium measurement
1
1
1
57.7
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
57.7
calcium measurement
1
57.7
Pathways (7)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Protein-Protein Interactions (297)
1 – 10 of 297
EEF1D
Tbio
Novelty: 0.02480745
p_int: 0.999988594
p_ni: 0.000011406
Score: 0.829
Data Source: BioPlex,STRINGDB
EEF1G
Tbio
Novelty: 0.01473013
p_int: 0.99998633
p_ni: 0.00001367
Score: 0.997
Data Source: BioPlex,STRINGDB
EEF1A1
Tchem
Novelty: 0.00059953
p_int: 0.99996164
p_ni: 0.00003836
Score: 0.942
Data Source: BioPlex,STRINGDB
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.99990079
p_ni: 0.00009921
Score: 0.894
Data Source: BioPlex,STRINGDB
ABTB1
Tbio
Novelty: 0.08918942
p_int: 0.998282948
p_ni: 0.001717052
Score: 0.859
Data Source: BioPlex,STRINGDB
MLLT6
Tdark
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.992557929
p_ni: 0.007442071
Score: 0.804
Data Source: BioPlex,STRINGDB
LITAF
Tbio
Family: TF
Novelty: 0.0097203
p_int: 0.895067661
p_ni: 0.104932339
Data Source: BioPlex
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.801582034
p_ni: 0.198417966
Score: 0.323
Data Source: BioPlex,STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.986
Data Source: STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.86

PubMed score by year
PubTator Score  129.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer