Tbio AARS Alanine--tRNA ligase, cytoplasmic

Protein Summary

Description

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438). The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49588
• A6NF14
• B4DR45
• Q53GV7
• Q96FA0

Gene Name

• AARS

Ensembl ID

• ENST00000261772
• ENSP00000261772
• ENSG00000090861

Symbol

• CMT2N
• EIEE29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
molecular function	0.99
protein domain	0.99
interacting protein	0.97
virus perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Alanine--trna Ligase, Cytoplasmic

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Alanine--trna Ligase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 687.55   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 687.55   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0