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Tbio
AARS
Alanine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438). The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261772
  • ENSP00000261772
  • ENSG00000090861

Symbol
  • CMT2N
  • EIEE29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
0.99
protein domain
0.99
interacting protein
0.97
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.64   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 540.64   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
38.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
38.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alanyl-tRNA synthetase
VGNC:13648
454210
Macaque
alanyl-tRNA synthetase
709492
Mouse
MGI:2384560
234734
Rat
RGD:1304832
292023
Dog
alanyl-tRNA synthetase
VGNC:37415
479656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alanyl-tRNA synthetase
Macaque
alanyl-tRNA synthetase
Mouse
Rat
Dog
alanyl-tRNA synthetase
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49588-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Gene Ontology Terms (20)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (162)
1 – 10 of 162
NARS
Tbio
Family: Enzyme
Novelty: 0.01124207
Score: 0.994
Data Source: STRINGDB
GARS
Tbio
Family: Enzyme
Novelty: 0.00190498
Score: 0.994
Data Source: STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.99
Data Source: STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.99
Data Source: STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
Score: 0.989
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.988
Data Source: STRINGDB
QARS
Tchem
Family: Enzyme
Novelty: 0.01684657
Score: 0.983
Data Source: STRINGDB
TARSL2
Tbio
Family: Enzyme
Novelty: 0.02406282
Score: 0.98
Data Source: STRINGDB
SARS
Tbio
Family: Enzyme
Novelty: 0.00963508
Score: 0.979
Data Source: STRINGDB
MARS
Tchem
Family: Enzyme
Novelty: 0.01318702
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  540.64

PubMed score by year
PubTator Score  155.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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