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Tbio
UBE2A
Ubiquitin-conjugating enzyme E2 A

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371558
  • ENSP00000360613
  • ENSG00000077721
  • ENST00000625938
  • ENSP00000486599
  • ENST00000630695
  • ENSP00000486550

Symbol
  • RAD6A
  • UBC2
  • HHR6A
  • MRXSN
  • RAD6A
  • MRXS30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
0.96
kinase perturbation
0.93
virus perturbation
0.85
transcription factor perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.19   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.19   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 A
VGNC:2659
737175
Macaque
ubiquitin conjugating enzyme E2 A
693716
Mouse
MGI:102959
22209
Rat
RGD:1359534
298317
Dog
ubiquitin conjugating enzyme E2 A
VGNC:54384
492095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 A
Macaque
ubiquitin conjugating enzyme E2 A
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49459-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
E3 ubiquitin ligases ubiquitinate target proteins
Immune System
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (430)
1 – 10 of 430
JPH4
Tbio
Novelty: 0.07699598
p_int: 0.972244654
p_ni: 0.027750689
p_wrong: 0.000004657
Score: 0.181
Data Source: BioPlex,STRINGDB
UBE2B
Tbio
Novelty: 0.01578275
p_int: 0.891075445
p_ni: 0.108924555
Score: 0.961
Data Source: BioPlex,STRINGDB
LLGL2
Tbio
Novelty: 0.07084531
p_int: 0.863518221
p_ni: 0.136385079
p_wrong: 0.0000967
Data Source: BioPlex
RNF20
Tbio
Family: Enzyme
Novelty: 0.01238827
Score: 0.995
Data Source: STRINGDB
RNF40
Tbio
Family: Enzyme
Novelty: 0.07038528
Score: 0.994
Data Source: STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
Score: 0.993
Data Source: STRINGDB
UBR2
Tbio
Family: Enzyme
Novelty: 0.03126228
Score: 0.992
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00419724
Score: 0.989
Data Source: STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.981
Data Source: STRINGDB
UBE2V1
Tbio
Novelty: 0.01642178
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.19

PubMed score by year
PubTator Score  21.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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