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Tbio
SRP9
Signal recognition particle 9 kDa protein

Protein Summary
Description
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304786
  • ENSP00000305230
  • ENSG00000143742
  • ENST00000366839
  • ENSP00000355804
  • ENST00000619790
  • ENSP00000485002

Symbol
  • ALURBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
transcription factor binding site profile
0.95
kinase perturbation
0.93
transcription factor perturbation
0.84
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
SRP54
Tbio
Novelty:  0.00535567
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
p_int:  0.999998951
p_ni:  0.00000102
p_wrong:  2.9e-8
Score:  0.663
Data Source:  BioPlex,STRINGDB
SRP68
Tbio
Novelty:  0.04666697
p_int:  0.999998249
p_ni:  0.000001751
Score:  0.999
Data Source:  BioPlex,STRINGDB
SRP19
Tbio
Novelty:  0.01831843
p_int:  0.999998159
p_ni:  0.000001829
p_wrong:  1.2e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
SRP14
Tbio
Novelty:  0.03745351
p_int:  0.999986306
p_ni:  0.000013694
Score:  0.999
Data Source:  BioPlex,STRINGDB
SRP72
Tbio
Novelty:  0.03264445
p_int:  0.999976389
p_ni:  0.000023611
Score:  0.999
Data Source:  BioPlex,STRINGDB
MTHFD2L
Tdark
Family:  Enzyme
Novelty:  0.18530504
p_int:  0.998680253
p_ni:  0.000028084
p_wrong:  0.001291663
Score:  0.719
Data Source:  BioPlex,STRINGDB
EDA
Tbio
Novelty:  0.00352464
p_int:  0.99721563
p_ni:  0.00278437
Data Source:  BioPlex
MTHFD2
Tchem
Family:  Enzyme
Novelty:  0.01776594
p_int:  0.992219216
p_ni:  0.007780784
Score:  0.768
Data Source:  BioPlex,STRINGDB
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
p_int:  0.982502155
p_ni:  0.017497843
p_wrong:  2e-9
Score:  0.775
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
SRP-dependent cotranslational protein targeting to membrane
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
74.3
lymphocyte count
2
2
2
71.2
sex hormone-binding globulin measurement
2
1
2
56.4
mean corpuscular volume
1
1
1
32.9
red blood cell distribution width
2
1
2
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
74.3
lymphocyte count
2
71.2
sex hormone-binding globulin measurement
2
56.4
mean corpuscular volume
1
32.9
red blood cell distribution width
2
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal recognition particle 9
VGNC:1567
736942
Macaque
signal recognition particle 9
700304
Mouse
MGI:1350930
27058
Rat
RGD:1597343
690345
Dog
signal recognition particle 9
VGNC:46810
611923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal recognition particle 9
Macaque
signal recognition particle 9
Mouse
Rat
Dog
signal recognition particle 9
Publication Statistics
PubMed Score 50.31
PubMed score by year
PubTator Score 35.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title