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Tbio
CENPF
Centromere protein F

Protein Summary
Description
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity ag ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366955
  • ENSP00000355922
  • ENSG00000117724

Symbol
  • CENF
  • hcp-1
  • CILD31
  • STROMS
  • PRO1779
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
virus perturbation
0.95
transcription factor perturbation
0.91
co-expressed gene
0.85
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.96   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.96   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
53.3
birth weight
1
1
1
48.5
inflammatory biomarker measurement
1
1
0
20.1
28.1
glomerular filtration rate
3
1
3
13.6
creatinine measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
53.3
birth weight
1
48.5
inflammatory biomarker measurement
0
20.1
28.1
glomerular filtration rate
3
13.6
creatinine measurement
1
7.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein F
VGNC:490
457733
Macaque
centromere protein F
709000
Mouse
MGI:1313302
108000
Rat
RGD:628667
257649
Horse
centromere protein F
VGNC:16394
100050180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein F
Macaque
centromere protein F
Mouse
Rat
Horse
centromere protein F
Protein Structure (0 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (41)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (320)
1 – 10 of 320
CCDC33
Tdark
Novelty:  0.17166818
p_int:  0.999999126
p_ni:  8.74e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999999027
p_ni:  9.7e-7
p_wrong:  3e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999988595
p_ni:  0.000011405
Score:  0.379
Data Source:  BioPlex,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.999987051
p_ni:  0.000012949
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999948601
p_ni:  0.000051399
Data Source:  BioPlex
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999822276
p_ni:  0.000177724
Data Source:  BioPlex
CCDC68
Tbio
Novelty:  0.1262502
p_int:  0.9995806
p_ni:  0.0004194
Score:  0.31
Data Source:  BioPlex,STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.999287602
p_ni:  0.000712392
p_wrong:  6e-9
Score:  0.434
Data Source:  BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.997148095
p_ni:  0.002851901
p_wrong:  4e-9
Data Source:  BioPlex
MTMR9
Tbio
Novelty:  0.09702778
p_int:  0.992478305
p_ni:  0.007521662
p_wrong:  3.3e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  158.96

PubMed score by year
PubTator Score  106.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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