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Tbio
CENPA
Histone H3-like centromeric protein A

Protein Summary
Description
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromoso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233505
  • ENSP00000233505
  • ENSG00000115163
  • ENST00000335756
  • ENSP00000336868

Symbol
  • CenH3
  • CENP-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor perturbation
0.91
histone modification site profile
0.85
transcription factor binding site profile
0.83
disease perturbation
0.74


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.16   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 670.16   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein A
VGNC:191
459086
Macaque
centromere protein A
697312
Mouse
MGI:88375
12615
Rat
RGD:1563607
298850
Dog
centromere protein A
VGNC:39101
475692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein A
Macaque
centromere protein A
Mouse
Rat
Dog
centromere protein A
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49450-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (383)
1 – 10 of 383
HJURP
Tbio
Novelty: 0.02317704
p_int: 0.999939761
p_ni: 0.000060239
Score: 0.999
Data Source: BioPlex,STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01026868
p_int: 0.988786627
p_ni: 0.011213373
Score: 0.732
Data Source: BioPlex,STRINGDB
OIP5
Tbio
Novelty: 0.02546471
p_int: 0.960824529
p_ni: 0.001275148
p_wrong: 0.037900323
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
ARL10
Tdark
Family: Enzyme
Novelty: 1.16329406
p_int: 0.915470298
p_ni: 0.084529702
Score: 0.164
Data Source: BioPlex,STRINGDB
MIS18A
Tbio
Novelty: 0.08143008
p_int: 0.884090745
p_ni: 0.003474133
p_wrong: 0.112435122
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
p_int: 0.848212092
p_ni: 0.151787908
Score: 0.774
Data Source: BioPlex,STRINGDB
H2AFY
Tbio
Novelty: 0.01150729
p_int: 0.831402262
p_ni: 0.168597738
Score: 0.857
Data Source: BioPlex,STRINGDB
MCM4
Tbio
Novelty: 0.00604311
p_int: 0.798665861
p_ni: 0.201334139
Score: 0.882
Data Source: BioPlex,STRINGDB
CENPN
Tbio
Novelty: 0.06923443
Score: 0.999
Data Source: STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  670.16

PubMed score by year
PubTator Score  386.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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