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Tbio
GLUD2
Glutamate dehydrogenase 2, mitochondrial

Protein Summary
Description
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328078
  • ENSP00000327589
  • ENSG00000182890

Symbol
  • GLUDP1
  • GDH2
  • GLUDP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
tissue
0.65
pathway
0.59
protein domain
0.58
tissue sample
0.57


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.62   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.62   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Xenopus
glutamate dehydrogenase 1
XB-GENE-1009691
496554
Zebrafish
ZDB-GENE-030828-1
373092
C. elegans
178130
S.cerevisiae
S000005902
854557
Species
Name
OMA
EggNOG
Inparanoid
Xenopus
glutamate dehydrogenase 1
Zebrafish
C. elegans
S.cerevisiae
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49448-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Glutamate and glutamine metabolism (R-HSA-8964539)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Protein-Protein Interactions (132)
1 – 10 of 132
KLHL22
Tbio
Novelty:  0.24456252
p_int:  1
Score:  0.732
Data Source:  BioPlex,STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
p_int:  0.811162024
p_ni:  0.188837976
Score:  0.994
Data Source:  BioPlex,STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.978
Data Source:  STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
Score:  0.978
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.973
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.958
Data Source:  STRINGDB
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
Score:  0.955
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.952
Data Source:  STRINGDB
GPT
Tbio
Family:  Enzyme
Novelty:  0.00003498
Score:  0.948
Data Source:  STRINGDB
ALDH4A1
Tbio
Family:  Enzyme
Novelty:  0.01316227
Score:  0.948
Data Source:  STRINGDB
Publication Statistics
PubMed Score  67.62

PubMed score by year
PubTator Score  59.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer