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Tbio
CDC34
Ubiquitin-conjugating enzyme E2 R1

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:22496338). Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215574
  • ENSP00000215574
  • ENSG00000099804

Symbol
  • UBCH3
  • UBE2R1
  • UBC3
  • UBCH3
  • UBE2R1
  • E2-CDC34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.96
hub protein
0.95
virus perturbation
0.76
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.34   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.34   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (413)
UBE2R2
Tbio
Novelty:  0.29593236
p_int:  0.999997339
p_ni:  4e-9
p_wrong:  0.000002657
Score:  0.903
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999989963
p_ni:  0.000005884
p_wrong:  0.000004154
Score:  0.973
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.999986422
p_ni:  0.000013578
Score:  0.944
Data Source:  BioPlex,STRINGDB
TCEANC2
Tdark
Novelty:  0.40325323
p_int:  0.999967589
p_ni:  0.00003241
p_wrong:  1e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
CTC1
Tbio
Novelty:  0.01298038
p_int:  0.994328231
p_ni:  0.005671574
p_wrong:  1.95e-7
Data Source:  BioPlex
SPRYD4
Tdark
Novelty:  0.44404169
p_int:  0.880552958
p_ni:  0.119446852
p_wrong:  1.9e-7
Data Source:  BioPlex
STT3B
Tbio
Family:  Enzyme
Novelty:  0.05813174
p_int:  0.873846915
p_ni:  0.126152492
p_wrong:  5.93e-7
Data Source:  BioPlex
UBC
Tbio
Novelty:  0.00204643
Score:  0.998
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.996
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.6
reticulocyte measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.6
reticulocyte measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 34
VGNC:2365
749854
Mouse
MGI:102657
216150
Rat
RGD:1305411
299602
Dog
cell division cycle 34
VGNC:38993
476759
Cow
cell division cycle 34
VGNC:27066
616156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 34
Mouse
Rat
Dog
cell division cycle 34
Cow
cell division cycle 34
Publication Statistics
PubMed Score 155.34
PubMed score by year
PubTator Score 56.97
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title