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Tbio
ALDH7A1
Alpha-aminoadipic semialdehyde dehydrogenase

Protein Summary
Description
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409134
  • ENSP00000387123
  • ENSG00000164904
  • ENST00000553117
  • ENSP00000448593

Symbol
  • ATQ1
  • EPD
  • PDE
  • ATQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.94
transcription factor binding site profile
0.82
protein domain
0.73
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.43   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.43   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.3
68.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.3
68.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108186
110695
Rat
RGD:1308614
291450
Dog
aldehyde dehydrogenase 7 family member A1
VGNC:37789
481486
Horse
aldehyde dehydrogenase 7 family member A1
VGNC:15239
100063766
Cow
aldehyde dehydrogenase 7 family member A1
VGNC:25818
507477
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
aldehyde dehydrogenase 7 family member A1
Horse
aldehyde dehydrogenase 7 family member A1
Cow
aldehyde dehydrogenase 7 family member A1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49419-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Choline catabolism (R-HSA-6798163)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Choline catabolism
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Choline catabolism
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (194)
1 – 10 of 194
XRCC4
Tbio
Novelty: 0.00305644
p_int: 0.998438517
p_ni: 0.001561483
Score: 0.35
Data Source: BioPlex,STRINGDB
L3HYPDH
Tdark
Family: Enzyme
Novelty: 0.35456591
p_int: 0.954394106
p_ni: 0.045605894
Score: 0.378
Data Source: BioPlex,STRINGDB
CST5
Tbio
Novelty: 0.04273227
p_int: 0.92956928
p_ni: 0.07043072
Data Source: BioPlex
CHDH
Tbio
Family: Enzyme
Novelty: 0.02147468
Score: 0.974
Data Source: STRINGDB
AASS
Tbio
Family: Enzyme
Novelty: 0.03213727
Score: 0.967
Data Source: STRINGDB
ABAT
Tclin
Family: Enzyme
Novelty: 0.0078359
Score: 0.956
Data Source: STRINGDB
BHMT
Tchem
Family: Enzyme
Novelty: 0.00453508
Score: 0.943
Data Source: STRINGDB
SMOX
Tbio
Family: Enzyme
Novelty: 0.0071711
Score: 0.937
Data Source: STRINGDB
ALDH6A1
Tbio
Family: Enzyme
Novelty: 0.03785268
Score: 0.928
Data Source: STRINGDB
HIBADH
Tbio
Family: Enzyme
Novelty: 0.03861647
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  1297.43

PubMed score by year
PubTator Score  212.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer