Tbio AMPH Amphiphysin

Protein Summary

Description

May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P49418
• A4D1X8
• A4D1X9
• O43538
• Q75MJ8
• Q75MK5
• Q75MM3
• Q8N4G0

Gene Name

• AMPH

Ensembl ID

• ENST00000325590
• ENSP00000317441
• ENSG00000078053
• ENST00000356264
• ENSP00000348602

Symbol

• AMPH1
• AMPH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
kinase	0.87
trait	0.86
hub protein	0.82
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.4   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 460   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.4   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 460   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0