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Tbio
ARRB1
Beta-arrestin-1

Protein Summary
Description
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360025
  • ENSP00000353124
  • ENSG00000137486
  • ENST00000420843
  • ENSP00000409581

Symbol
  • ARR1
  • ARB1
  • ARR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
disease perturbation
0.96
interacting protein
0.95


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.69   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.69   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arrestin beta 1
VGNC:11261
451424
Macaque
arrestin beta 1
695250
Mouse
MGI:99473
109689
Rat
RGD:2156
25387
Dog
arrestin beta 1
VGNC:38136
485189
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arrestin beta 1
Macaque
arrestin beta 1
Mouse
Rat
Dog
arrestin beta 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49407-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (65)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Activation of SMO
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Cytokine Signaling in Immune system
Gene Ontology Terms (74)
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (781)
1 – 10 of 781
ARRB2
Tbio
Novelty: 0.00148149
p_int: 1
Score: 0.968
Data Source: BioPlex,STRINGDB
SAG
Tbio
Novelty: 0.00040944
p_int: 0.999999994
p_wrong: 6e-9
Score: 0.427
Data Source: BioPlex,STRINGDB
BRPF1
Tchem
Family: Epigenetic
Novelty: 0.02524021
p_int: 0.99999922
p_ni: 7.76e-7
p_wrong: 4e-9
Score: 0.82
Data Source: BioPlex,STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
p_int: 0.999715915
p_ni: 0.000267235
p_wrong: 0.00001685
Score: 0.821
Data Source: BioPlex,STRINGDB
NOLC1
Tbio
Novelty: 0.01922261
p_int: 0.999652607
p_ni: 0.000347393
Score: 0.602
Data Source: BioPlex,STRINGDB
DOCK4
Tbio
Novelty: 0.02356655
p_int: 0.999618081
p_ni: 0.000381918
Score: 0.189
Data Source: BioPlex,STRINGDB
ALDH4A1
Tbio
Family: Enzyme
Novelty: 0.01316227
p_int: 0.997706757
p_ni: 0.001123693
p_wrong: 0.00116955
Score: 0.331
Data Source: BioPlex,STRINGDB
LYRM7
Tbio
Novelty: 0.16270565
p_int: 0.993036822
p_ni: 0.006884987
p_wrong: 0.000078191
Data Source: BioPlex
ACIN1
Tbio
Novelty: 0.01675479
p_int: 0.941516508
p_ni: 0.058483492
Data Source: BioPlex
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.937476039
p_ni: 0.055005481
p_wrong: 0.00751848
Score: 0.237
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  382.69

PubMed score by year
PubTator Score  563.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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