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Tbio
CCT3
T-complex protein 1 subunit gamma

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295688
  • ENSP00000295688
  • ENSG00000163468
  • ENST00000368259
  • ENSP00000357242

Symbol
  • CCTG
  • TRIC5
  • CCTG
  • PIG48
  • TRIC5
  • CCT-gamma
  • TCP-1-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
disease perturbation
0.98
kinase perturbation
0.97
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.86   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.86   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
94.7
HbA1c measurement
5
5
5
92
mean corpuscular volume
2
2
2
90.1
mean corpuscular hemoglobin concentration
3
3
3
81.7
TPE interval measurement
1
1
3
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
94.7
HbA1c measurement
5
92
mean corpuscular volume
2
90.1
mean corpuscular hemoglobin concentration
3
81.7
TPE interval measurement
3
79.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 3
VGNC:6733
741752
Macaque
chaperonin containing TCP1 subunit 3
718374
Mouse
MGI:104708
12462
Rat
RGD:735038
295230
Dog
chaperonin containing TCP1 subunit 3
VGNC:38923
480123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 3
Macaque
chaperonin containing TCP1 subunit 3
Mouse
Rat
Dog
chaperonin containing TCP1 subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49368-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (486)
1 – 10 of 486
TUBD1
Tbio
Novelty:  0.03591414
p_int:  0.999992366
p_ni:  0.00000673
p_wrong:  9.04e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
DCAF12
Tbio
Novelty:  0.15472702
p_int:  0.999980088
p_ni:  0.000019912
Score:  0.232
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999973712
p_ni:  0.000026288
Score:  0.999
Data Source:  BioPlex,STRINGDB
TXNDC9
Tbio
Novelty:  0.00309772
p_int:  0.999925753
p_ni:  0.000074247
Score:  0.758
Data Source:  BioPlex,STRINGDB
DTL
Tbio
Novelty:  0.01659105
p_int:  0.999808851
p_ni:  0.000191149
Score:  0.22
Data Source:  BioPlex,STRINGDB
WDR70
Tdark
Novelty:  0.37521871
p_int:  0.999798524
p_ni:  0.000201475
Data Source:  BioPlex
DCAF13
Tbio
Novelty:  0.02796363
p_int:  0.999546534
p_ni:  0.000453414
p_wrong:  5.2e-8
Score:  0.461
Data Source:  BioPlex,STRINGDB
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999052035
p_ni:  0.000947935
p_wrong:  3e-8
Data Source:  BioPlex
FBXW4
Tbio
Novelty:  0.06255177
p_int:  0.998707234
p_ni:  0.001292766
Score:  0.96
Data Source:  BioPlex,STRINGDB
CERCAM
Tdark
Family:  Enzyme
Novelty:  0.33392502
p_int:  0.998402165
p_ni:  0.001597836
Data Source:  BioPlex
Publication Statistics
PubMed Score  63.86

PubMed score by year
PubTator Score  85.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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