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Tbio
CCT3
T-complex protein 1 subunit gamma

Protein Classes
Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295688
  • ENSP00000295688
  • ENSG00000163468
  • ENST00000368259
  • ENSP00000357242

Symbol
  • CCTG
  • TRIC5
  • CCTG
  • PIG48
  • TRIC5
  • CCT-gamma
  • TCP-1-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
disease perturbation
0.98
kinase perturbation
0.97
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.57   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.57   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (13)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (486)
1 – 10 of 486
TUBD1
Tbio
Novelty: 0.05057515
p_int: 0.999992366
p_ni: 0.00000673
p_wrong: 9.04e-7
Score: 0.195
Data Source: BioPlex,STRINGDB
DCAF12
Tbio
Novelty: 0.09567198
p_int: 0.999980088
p_ni: 0.000019912
Score: 0.232
Data Source: BioPlex,STRINGDB
CCT7
Tbio
Novelty: 0.03353089
p_int: 0.999973712
p_ni: 0.000026288
Score: 0.999
Data Source: BioPlex,STRINGDB
TXNDC9
Tbio
Novelty: 0.00444155
p_int: 0.999925753
p_ni: 0.000074247
Score: 0.758
Data Source: BioPlex,STRINGDB
DTL
Tbio
Novelty: 0.01976973
p_int: 0.999808851
p_ni: 0.000191149
Score: 0.22
Data Source: BioPlex,STRINGDB
WDR70
Tdark
Novelty: 1.2244898
p_int: 0.999798524
p_ni: 0.000201475
Data Source: BioPlex
DCAF13
Tbio
Novelty: 0.00828554
p_int: 0.999546534
p_ni: 0.000453414
p_wrong: 5.2e-8
Score: 0.461
Data Source: BioPlex,STRINGDB
JMJD4
Tbio
Novelty: 0.13265189
p_int: 0.999052035
p_ni: 0.000947935
p_wrong: 3e-8
Data Source: BioPlex
FBXW4
Tbio
Novelty: 0.0652799
p_int: 0.998707234
p_ni: 0.001292766
Score: 0.96
Data Source: BioPlex,STRINGDB
CERCAM
Tdark
Family: Enzyme
Novelty: 0.47058824
p_int: 0.998402165
p_ni: 0.001597836
Data Source: BioPlex
Publication Statistics
PubMed Score  175.57

PubMed score by year
PubTator Score  85.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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