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Tchem
DHPS
Deoxyhypusine synthase

Protein Summary
Description
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000210060
  • ENSP00000210060
  • ENSG00000095059
  • ENST00000351660
  • ENSP00000221303
  • ENST00000594424
  • ENSP00000471886

Symbol
  • DS
  • DS
  • DHS
  • MIG13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
kinase perturbation
0.76
transcription factor perturbation
0.74
histone modification site profile
0.73
biological process
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.14   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.14   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (91)
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.999999572
p_ni:  4.28e-7
Score:  0.231
Data Source:  BioPlex,STRINGDB
EIF5A2
Tbio
Novelty:  0.01527502
p_int:  0.999999571
p_ni:  4.29e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SUSD4
Tbio
Novelty:  0.22201938
p_int:  0.999994801
p_ni:  0.000005199
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.999986834
p_ni:  0.000013166
Data Source:  BioPlex
SAFB2
Tbio
Novelty:  0.12354864
p_int:  0.99978159
p_ni:  0.00021841
Score:  0.17
Data Source:  BioPlex,STRINGDB
ARHGAP15
Tbio
Family:  Enzyme
Novelty:  0.09749237
p_int:  0.999600234
p_ni:  0.000399766
Score:  0.252
Data Source:  BioPlex,STRINGDB
TIRAP
Tbio
Novelty:  0.00600495
p_int:  0.999568534
p_ni:  0.000431466
Score:  0.198
Data Source:  BioPlex,STRINGDB
ZNF276
Tdark
Family:  TF
Novelty:  0.3082638
p_int:  0.999540755
p_ni:  0.000459245
Data Source:  BioPlex
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.993129431
p_ni:  0.006870569
Data Source:  BioPlex
RPL9
Tbio
Novelty:  0.00845583
p_int:  0.98779076
p_ni:  0.012209235
p_wrong:  6e-9
Score:  0.344
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Hypusine synthesis from eIF5A-lysine
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Hypusine synthesis from eIF5A-lysine
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
1
1
42.3
body height
1
1
1
24.5
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
42.3
body height
1
24.5
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxyhypusine synthase
VGNC:2572
455746
Macaque
deoxyhypusine synthase
716213
Mouse
MGI:2683592
330817
Rat
RGD:1303326
288923
Dog
deoxyhypusine synthase
VGNC:39931
476702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxyhypusine synthase
Macaque
deoxyhypusine synthase
Mouse
Rat
Dog
deoxyhypusine synthase
Publication Statistics
PubMed Score 126.14
PubMed score by year
PubTator Score 161.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title