Protein Summary
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple is ...more
- ENST00000210060
- ENSP00000210060
- ENSG00000095059
- ENST00000351660
- ENSP00000221303
- ENST00000594424
- ENSP00000471886
- DS
- DS
- DHS
- MIG13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.85 | ||
kinase perturbation | 0.76 | ||
transcription factor perturbation | 0.74 | ||
histone modification site profile | 0.73 | ||
biological process | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.14 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 281 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.14 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 281 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (91)
BYSL
Novelty: 0.01919968
p_int: 0.999999572
p_ni: 4.28e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
EIF5A2
Novelty: 0.01527502
p_int: 0.999999571
p_ni: 4.29e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SAFB2
Novelty: 0.12354864
p_int: 0.99978159
p_ni: 0.00021841
Score: 0.17
Data Source: BioPlex,STRINGDB
ARHGAP15
Family: Enzyme
Novelty: 0.09749237
p_int: 0.999600234
p_ni: 0.000399766
Score: 0.252
Data Source: BioPlex,STRINGDB
TIRAP
Novelty: 0.00600495
p_int: 0.999568534
p_ni: 0.000431466
Score: 0.198
Data Source: BioPlex,STRINGDB
RPL9
Novelty: 0.00845583
p_int: 0.98779076
p_ni: 0.012209235
p_wrong: 6e-9
Score: 0.344
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Hypusine synthesis from eIF5A-lysine | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Hypusine synthesis from eIF5A-lysine | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cathepsin L1 measurement | 1 | 1 | 1 | 42.3 | |||||
body height | 1 | 1 | 1 | 24.5 | |||||
1 | 1 | 1 | 8.3 | ||||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cathepsin L1 measurement | 1 | 42.3 | |||||
body height | 1 | 24.5 | |||||
1 | 8.3 | ||||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | deoxyhypusine synthase | VGNC:2572 | 455746 | |||||
Macaque | deoxyhypusine synthase | 716213 | ||||||
Mouse | MGI:2683592 | 330817 | ||||||
Rat | RGD:1303326 | 288923 | ||||||
Dog | deoxyhypusine synthase | VGNC:39931 | 476702 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | deoxyhypusine synthase | |||||
Macaque | deoxyhypusine synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | deoxyhypusine synthase | |||||
Publication Statistics
PubMed Score 126.14
PubMed score by year
PubTator Score 161.13
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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