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Tchem
FNTB
Protein farnesyltransferase subunit beta

Protein Summary
Description
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246166
  • ENSP00000246166
  • ENSG00000257365

Symbol
  • FNTB
  • FTase-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor binding site profile
0.94
ligand (protein) perturbation
0.83
disease perturbation
0.74
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
2
3
91.9
mean corpuscular volume
2
2
2
84.4
red blood cell density measurement
1
1
1
81.8
mean platelet volume
3
1
3
81.5
reticulocyte measurement
3
2
3
67.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
91.9
mean corpuscular volume
2
84.4
red blood cell density measurement
1
81.8
mean platelet volume
3
81.5
reticulocyte measurement
3
67.6
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
GRIP1
Tbio
Novelty: 0.00343871
p_int: 1
Score: 0.228
Data Source: BioPlex,STRINGDB
FNTA
Tbio
Family: Enzyme
Novelty: 0.03163169
p_int: 0.999999968
p_ni: 3.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SPDL1
Tbio
Novelty: 0.01399644
p_int: 0.999998719
p_ni: 0.000001281
Data Source: BioPlex
CAPN1
Tchem
Novelty: 0.00252811
p_int: 0.999997312
p_ni: 0.000002688
Score: 0.217
Data Source: BioPlex,STRINGDB
NAP1L1
Tbio
Novelty: 0.03895314
p_int: 0.99999539
p_ni: 0.00000461
Score: 0.224
Data Source: BioPlex,STRINGDB
CENPF
Tbio
Novelty: 0.00676983
p_int: 0.999988595
p_ni: 0.000011405
Score: 0.379
Data Source: BioPlex,STRINGDB
DYRK1A
Tchem
Family: Kinase
Novelty: 0.00226963
p_int: 0.999851317
p_ni: 0.000148683
Score: 0.565
Data Source: BioPlex,STRINGDB
HOOK3
Tbio
Novelty: 0.0553474
p_int: 0.999819684
p_ni: 0.000180316
Data Source: BioPlex
CAST
Tbio
Novelty: 0.00099404
p_int: 0.99973774
p_ni: 0.00026226
Score: 0.555
Data Source: BioPlex,STRINGDB
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.999645388
p_ni: 0.000354612
Data Source: BioPlex
Publication Statistics
PubMed Score  10.19

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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