Tclin FNTB Protein farnesyltransferase subunit beta

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Protein Farnesyltransferase Subunit Beta

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Protein Farnesyltransferase Subunit Beta

Protein Summary

Description

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P49356
• B2RDX6
• B4E1A0
• FTase-beta

Gene Name

• FNTB

Ensembl ID

• ENST00000246166
• ENSP00000246166
• ENSG00000257365

Symbol

• FNTB
• FTase-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
transcription factor binding site profile	0.94
ligand (protein) perturbation	0.83
disease perturbation	0.74
kinase perturbation	0.71

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.25   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.25   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

lonafarnib

FNTBTclin Enzyme

INHIBITOR IC50 : 8.72

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

BMS-214662

FNTBTclin Enzyme

IC50 : 8.86999989

FTI 276

FNTBTclin Enzyme

IC50 : 9.30000019

L-739,750

FNTBTclin Enzyme

IC50 : 8.73999977

tipifarnib

FNTBTclin Enzyme

IC50 : 9.06999969

GWAS Traits (21)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	4	3	4		98
reticulocyte measurement	EFO_0010700	3	2	3		90.2
mean corpuscular volume	EFO_0004526	2	3	3		89.9
reticulocyte count	EFO_0007986	2	2	2		86.6
red blood cell density measurement	EFO_0007978	1	1	1		82.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	4		98
reticulocyte measurement	EFO_0010700	3		90.2
mean corpuscular volume	EFO_0004526	3		89.9
reticulocyte count	EFO_0007986	2		86.6
red blood cell density measurement	EFO_0007978	1		82.5

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	farnesyltransferase, CAAX box, beta		452971
Macaque	CHURC1-FNTB readthrough [Source:HGNC Symbol;Acc:HGNC:42960]
Mouse	farnesyltransferase, CAAX box, beta	MGI:1861305	110606
Rat	farnesyltransferase, CAAX box, beta	RGD:620119	64511
Dog	farnesyltransferase, CAAX box, beta		490735

Species	Name	OMA	EggNOG	Inparanoid
Chimp	farnesyltransferase, CAAX box, beta
Macaque	CHURC1-FNTB readthrough [Source:HGNC Symbol;Acc:HGNC:42960]
Mouse	farnesyltransferase, CAAX box, beta
Rat	farnesyltransferase, CAAX box, beta
Dog	farnesyltransferase, CAAX box, beta

Protein Structure (14 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49356-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (7)

Reactome (7)

G alpha (i) signalling events (R-HSA-418594)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	Inactivation, recovery and regulation of the phototransduction cascade	33 targets	R-HSA-2514859
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
Inactivation, recovery and regulation of the phototransduction cascade	33 targets	R-HSA-2514859
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Gene Ontology Terms (19)

Functions (6)

Components (3)

Processes (10)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
protein farnesyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
zinc ion binding	Inferred from Direct Assay (IDA)	UniProtKB
drug binding	Inferred from Electronic Annotation (IEA)	Ensembl
farnesyltranstransferase activity	Inferred from Electronic Annotation (IEA)	Ensembl
isoprenoid binding	Inferred from Electronic Annotation (IEA)	Ensembl
peptide binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

GRIP1

Tbio

Novelty:  0.00343871

p_int:  1

Score:  0.228

Data Source:  BioPlex,STRINGDB

FNTA

Tclin

Family:  Enzyme

Novelty:  0.03163169

p_int:  0.999999968

p_ni:  3.2e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SPDL1

Tbio

Novelty:  0.01399644

p_int:  0.999998719

p_ni:  0.000001281

Data Source:  BioPlex

CAPN1

Tchem

Novelty:  0.00252811

p_int:  0.999997312

p_ni:  0.000002688

Score:  0.217

Data Source:  BioPlex,STRINGDB

NAP1L1

Tbio

Novelty:  0.03895314

p_int:  0.99999539

p_ni:  0.00000461

Score:  0.224

Data Source:  BioPlex,STRINGDB

CENPF

Tbio

Novelty:  0.00676983

p_int:  0.999988595

p_ni:  0.000011405

Score:  0.379

Data Source:  BioPlex,STRINGDB

DYRK1A

Tchem

Family:  Kinase

Novelty:  0.00226963

p_int:  0.999851317

p_ni:  0.000148683

Score:  0.565

Data Source:  BioPlex,STRINGDB

HOOK3

Tbio

Novelty:  0.0553474

p_int:  0.999819684

p_ni:  0.000180316

Data Source:  BioPlex

CAST

Tbio

Novelty:  0.00099404

p_int:  0.99973774

p_ni:  0.00026226

Score:  0.555

Data Source:  BioPlex,STRINGDB

RPL18

Tbio

Novelty:  0.01765545

p_int:  0.999645388

p_ni:  0.000354612

Data Source:  BioPlex

Publication Statistics

PubMed Score  10.25

PubMed score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Metal-binding
Phosphoprotein
Prenyltransferase
Reference proteome
Repeat
Transferase
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
body height
eosinophil count
eosinophil percentage of leukocytes
erythrocyte count
erythrocyte measurement
hemoglobin measurement
leukocyte count
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
neoplasm
skeleton phenotype