FNTB
Protein farnesyltransferase subunit beta
Protein Summary
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
- ENST00000246166
- ENSP00000246166
- ENSG00000257365
- FNTB
- FTase-beta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
transcription factor binding site profile | 0.94 | ||
ligand (protein) perturbation | 0.83 | ||
disease perturbation | 0.74 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.25 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 238 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.25 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 238 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (1)
Active Ligands (4)
Protein-Protein Interactions (77)
FNTA
Family: Enzyme
Novelty: 0.03163169
p_int: 0.999999968
p_ni: 3.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAPN1
Novelty: 0.00252811
p_int: 0.999997312
p_ni: 0.000002688
Score: 0.217
Data Source: BioPlex,STRINGDB
NAP1L1
Novelty: 0.03895314
p_int: 0.99999539
p_ni: 0.00000461
Score: 0.224
Data Source: BioPlex,STRINGDB
CENPF
Novelty: 0.00676983
p_int: 0.999988595
p_ni: 0.000011405
Score: 0.379
Data Source: BioPlex,STRINGDB
DYRK1A
Family: Kinase
Novelty: 0.00226963
p_int: 0.999851317
p_ni: 0.000148683
Score: 0.565
Data Source: BioPlex,STRINGDB
CAST
Novelty: 0.00099404
p_int: 0.99973774
p_ni: 0.00026226
Score: 0.555
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Inactivation, recovery and regulation of the phototransduction cascade | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (6)
Components (3)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 3 | 4 | 98 | |||||
reticulocyte measurement | 3 | 2 | 3 | 90.2 | |||||
mean corpuscular volume | 2 | 3 | 3 | 89.9 | |||||
reticulocyte count | 2 | 2 | 2 | 86.6 | |||||
red blood cell density measurement | 1 | 1 | 1 | 82.5 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 4 | 98 | |||||
reticulocyte measurement | 3 | 90.2 | |||||
mean corpuscular volume | 3 | 89.9 | |||||
reticulocyte count | 2 | 86.6 | |||||
red blood cell density measurement | 1 | 82.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | farnesyltransferase, CAAX box, beta | 452971 | ||||||
Macaque | CHURC1-FNTB readthrough [Source:HGNC Symbol;Acc:HGNC:42960] | |||||||
Mouse | MGI:1861305 | 110606 | ||||||
Rat | RGD:620119 | 64511 | ||||||
Dog | farnesyltransferase, CAAX box, beta | 490735 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | farnesyltransferase, CAAX box, beta | |||||
Macaque | CHURC1-FNTB readthrough [Source:HGNC Symbol;Acc:HGNC:42960] | |||||
Mouse | ||||||
Rat | ||||||
Dog | farnesyltransferase, CAAX box, beta | |||||
Publication Statistics
PubMed Score 10.25
PubMed score by year
Related Publications
Text Mined References (4)
Items per page:
0 of 0
PMID | Year | Title |
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