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Tclin
FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Protein Summary
Description
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302279
  • ENSP00000303423
  • ENSG00000168522

Symbol
  • FPTA
  • PTAR2
  • PGGT1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
virus perturbation
0.99
transcription factor perturbation
0.88
cell type or tissue
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
PGGT1B
Tchem
Family:  Enzyme
Novelty:  0.08041103
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999999968
p_ni:  3.2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
OGFOD1
Tbio
Family:  Enzyme
Novelty:  0.023983
p_int:  0.999999807
p_ni:  1.83e-7
p_wrong:  1e-8
Data Source:  BioPlex
AGMAT
Tbio
Family:  Enzyme
Novelty:  0.03970349
p_int:  0.999999375
p_ni:  1.26e-7
p_wrong:  4.99e-7
Data Source:  BioPlex
ZMYM1
Tdark
Novelty:  0.3860445
p_int:  0.999980405
p_ni:  0.000019595
Data Source:  BioPlex
AMMECR1L
Tdark
Novelty:  0.60058793
p_int:  0.99976076
p_ni:  0.000019611
p_wrong:  0.00021963
Score:  0.311
Data Source:  BioPlex,STRINGDB
NAP1L1
Tbio
Novelty:  0.03895314
p_int:  0.999318383
p_ni:  0.000681617
Score:  0.823
Data Source:  BioPlex,STRINGDB
CENPF
Tbio
Novelty:  0.00676983
p_int:  0.999287602
p_ni:  0.000712392
p_wrong:  6e-9
Score:  0.434
Data Source:  BioPlex,STRINGDB
YKT6
Tbio
Novelty:  0.01591063
p_int:  0.99926544
p_ni:  0.000734247
p_wrong:  3.13e-7
Data Source:  BioPlex
DYRK1A
Tchem
Family:  Kinase
Novelty:  0.00226963
p_int:  0.999113277
p_ni:  0.000886723
Score:  0.358
Data Source:  BioPlex,STRINGDB
Pathways (13)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104683
14272
Rat
RGD:2625
25318
Dog
farnesyltransferase, CAAX box, alpha
VGNC:40937
475566
Horse
farnesyltransferase, CAAX box, alpha [Source:HGNC Symbol;Acc:HGNC:3782]
Cow
farnesyltransferase, CAAX box, alpha
VGNC:29070
281169
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
farnesyltransferase, CAAX box, alpha
Horse
farnesyltransferase, CAAX box, alpha [Source:HGNC Symbol;Acc:HGNC:3782]
Cow
farnesyltransferase, CAAX box, alpha
Publication Statistics
PubMed Score 32.02
PubMed score by year
PubTator Score 17.04
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title