Pharos : Target Details

Tclin

Protein Summary

Description

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

Uniprot Accession IDs

Gene Name

FNTA

Ensembl ID

ENST00000302279
ENSP00000303423
ENSG00000168522

Symbol

FPTA
PTAR2
PGGT1A

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1

kinase perturbation	0.99

virus perturbation	0.99

transcription factor perturbation	0.88

cell type or tissue	0.81

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02 (req: < 5)

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Gene RIFs: 10 (req: <= 3)

View Gene RIFs

Antibodies: 287 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02 (req: >= 5)

Gene RIFs: 10 (req: > 3)

Antibodies: 287 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Explore Approved Drugs

Protein Sequence and Structure

Residue Counts

Protein Sequence

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ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

lonafarnib

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (100)

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1 – 10 of 100

See Interactions on String-DB

PGGT1B

Tchem

Family: Enzyme

Novelty: 0.08041103

p_int: 0.999999998

p_ni: 2e-9

Score: 0.999

Data Source: BioPlex,STRINGDB

FNTB

Tclin

Family: Enzyme

Novelty: 0.07434994

p_int: 0.999999968

p_ni: 3.2e-8

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

OGFOD1

Tbio

Family: Enzyme

Novelty: 0.023983

p_int: 0.999999807

p_ni: 1.83e-7

p_wrong: 1e-8

Data Source: BioPlex

AGMAT

Tbio

Family: Enzyme

Novelty: 0.03970349

p_int: 0.999999375

p_ni: 1.26e-7

p_wrong: 4.99e-7

Data Source: BioPlex

ZMYM1

Tdark

Novelty: 0.3860445

p_int: 0.999980405

p_ni: 0.000019595

Data Source: BioPlex

AMMECR1L

Tdark

Novelty: 0.60058793

p_int: 0.99976076

p_ni: 0.000019611

p_wrong: 0.00021963

Score: 0.311

Data Source: BioPlex,STRINGDB

NAP1L1

Tbio

Novelty: 0.03895314

p_int: 0.999318383

p_ni: 0.000681617

Score: 0.823

Data Source: BioPlex,STRINGDB

CENPF

Tbio

Novelty: 0.00676983

p_int: 0.999287602

p_ni: 0.000712392

p_wrong: 6e-9

Score: 0.434

Data Source: BioPlex,STRINGDB

YKT6

Tbio

Novelty: 0.01591063

p_int: 0.99926544

p_ni: 0.000734247

p_wrong: 3.13e-7

Data Source: BioPlex

DYRK1A

Tchem

Family: Kinase

Novelty: 0.00226963

p_int: 0.999113277

p_ni: 0.000886723

Score: 0.358

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (1)

1 – 1 of 1

FDPS

Tclin

Family: Enzyme

KEGG Distance: 1

Common Pathways: 1

1: Terpenoid backbone biosynthesis

Pathways (13)

Reactome (11)

KEGG (1)

PathwayCommons (1)

Apoptosis (R-HSA-109581)

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Items per page:

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581

Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465

Reactome	Apoptotic execution phase	52 targets	R-HSA-75153

Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594

Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581

Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465

Apoptotic execution phase	52 targets	R-HSA-75153

G alpha (i) signalling events	408 targets	R-HSA-418594

GPCR downstream signalling	1152 targets	R-HSA-388396

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (8)

Components (6)

Processes (7)

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GO Term	Evidence	Assigned by
alpha-tubulin binding	Inferred from Direct Assay (IDA)	BHF-UCL

microtubule binding	Inferred from Direct Assay (IDA)	BHF-UCL

protein farnesyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB

protein geranylgeranyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB

acetylcholine receptor regulator activity	Inferred from Electronic Annotation (IEA)	Ensembl

CAAX-protein geranylgeranyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Rab geranylgeranyltransferase activity	Inferred from Electronic Annotation (IEA)	Ensembl

receptor tyrosine kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
3D-structure

Acetylation

Alternative splicing

Complete proteome

Phosphoprotein

Prenyltransferase

Reference proteome

Repeat

Transferase

MGI Phenotype

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IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Mouse	farnesyltransferase, CAAX box, alpha	MGI:104683	14272

Rat	farnesyltransferase, CAAX box, alpha	RGD:2625	25318

Dog	farnesyltransferase, CAAX box, alpha	VGNC:40937	475566

Horse	farnesyltransferase, CAAX box, alpha [Source:HGNC Symbol;Acc:HGNC:3782]

Cow	farnesyltransferase, CAAX box, alpha	VGNC:29070	281169

Species	Name	OMA	EggNOG	Inparanoid
Mouse	farnesyltransferase, CAAX box, alpha

Rat	farnesyltransferase, CAAX box, alpha

Dog	farnesyltransferase, CAAX box, alpha

Horse	farnesyltransferase, CAAX box, alpha [Source:HGNC Symbol;Acc:HGNC:3782]

Cow	farnesyltransferase, CAAX box, alpha

Publication Statistics

PubMed Score 32.02

PubMed score by year

PubTator Score 17.04

PubTator score by year

Related Publications

Text Mined References (36)

GeneRif Annotations (10)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
growth/size/body region phenotype

homeostasis/metabolism phenotype

mortality/aging