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Tchem
CDK8
Cyclin-dependent kinase 8

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family memb ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381527
  • ENSP00000370938
  • ENSG00000132964

Symbol
  • K35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
disease perturbation
0.93
transcription factor binding site profile
0.88
histone modification site profile
0.84
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.33   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.33   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2