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Tchem
CDK8
Cyclin-dependent kinase 8

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family memb ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381527
  • ENSP00000370938
  • ENSG00000132964

Symbol
  • K35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
disease perturbation
0.93
transcription factor binding site profile
0.88
histone modification site profile
0.84
trait
0.75


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.72   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.72   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 98
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
sorafenib
chemical structure image
ponatinib
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
37
appendicular lean mass
1
1
1
21.7
mathematical ability
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
37
appendicular lean mass
1
21.7
mathematical ability
1
6.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 8
VGNC:7829
452501
Macaque
cyclin dependent kinase 8
709761
Mouse
MGI:1196224
264064
Dog
cyclin dependent kinase 8
VGNC:39061
486035
Horse
cyclin dependent kinase 8
VGNC:16356
100050819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 8
Macaque
cyclin dependent kinase 8
Mouse
Dog
cyclin dependent kinase 8
Horse
cyclin dependent kinase 8
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (191)
1 – 10 of 191
CCNC
Tbio
Novelty: 0.00585842
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDK19
Tchem
Family: Kinase
Novelty: 0.03132669
p_int: 1
Score: 0.982
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999999829
p_ni: 1.71e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999997249
p_ni: 0.000002751
Score: 0.993
Data Source: BioPlex,STRINGDB
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999994863
p_ni: 0.000005137
Score: 0.995
Data Source: BioPlex,STRINGDB
MED6
Tbio
Family: Enzyme
Novelty: 0.05215086
p_int: 0.999993113
p_ni: 0.000006887
Score: 0.996
Data Source: BioPlex,STRINGDB
MED8
Tbio
Family: Enzyme
Novelty: 0.06648307
p_int: 0.999927198
p_ni: 0.000072204
p_wrong: 5.98e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
MED13
Tbio
Family: Enzyme
Novelty: 0.02090708
p_int: 0.999926571
p_ni: 0.000073428
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
MED24
Tbio
Family: Enzyme
Novelty: 0.05466084
p_int: 0.999920819
p_ni: 0.000079181
Score: 0.99
Data Source: BioPlex,STRINGDB
MED12L
Tdark
Family: Enzyme
Novelty: 0.09658419
p_int: 0.999918151
p_ni: 0.000081849
Score: 0.978
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  224.72

PubMed score by year
PubTator Score  108.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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