Protein Summary
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family memb ...more
- ENST00000381527
- ENSP00000370938
- ENSG00000132964
- K35
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.95 | ||
disease perturbation | 0.93 | ||
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.84 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 233.53 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 408 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 233.53 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 408 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 190
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (190)
Protein-Protein Interactions (191)
MED1
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999999829
p_ni: 1.71e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED21
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999997249
p_ni: 0.000002751
Score: 0.993
Data Source: BioPlex,STRINGDB
MED19
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999994863
p_ni: 0.000005137
Score: 0.995
Data Source: BioPlex,STRINGDB
MED6
Family: Enzyme
Novelty: 0.05215086
p_int: 0.999993113
p_ni: 0.000006887
Score: 0.996
Data Source: BioPlex,STRINGDB
MED8
Family: Enzyme
Novelty: 0.06648307
p_int: 0.999927198
p_ni: 0.000072204
p_wrong: 5.98e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
MED13
Family: Enzyme
Novelty: 0.02090708
p_int: 0.999926571
p_ni: 0.000073428
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
MED24
Family: Enzyme
Novelty: 0.05466084
p_int: 0.999920819
p_ni: 0.000079181
Score: 0.99
Data Source: BioPlex,STRINGDB
MED12L
Family: Enzyme
Novelty: 0.09658419
p_int: 0.999918151
p_ni: 0.000081849
Score: 0.978
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (33)
Reactome (24)
PathwayCommons (6)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Developmental Biology | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (5)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
6 | 4 | 3 | 1.1 | 95.6 | |||||
glucose measurement | 1 | 1 | 1 | 64.4 | |||||
1 | 1 | 0 | 1.4 | 21.5 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 9.2 | |||||
appendicular lean mass | 1 | 1 | 1 | 9 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
3 | 1.1 | 95.6 | |||||
glucose measurement | 1 | 64.4 | |||||
0 | 1.4 | 21.5 | |||||
sex hormone-binding globulin measurement | 1 | 9.2 | |||||
appendicular lean mass | 1 | 9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase 8 | VGNC:7829 | 452501 | |||||
Macaque | cyclin dependent kinase 8 | 709761 | ||||||
Mouse | MGI:1196224 | 264064 | ||||||
Dog | cyclin dependent kinase 8 | VGNC:39061 | 486035 | |||||
Horse | cyclin dependent kinase 8 | VGNC:16356 | 100050819 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase 8 | |||||
Macaque | cyclin dependent kinase 8 | |||||
Mouse | ||||||
Dog | cyclin dependent kinase 8 | |||||
Horse | cyclin dependent kinase 8 | |||||
Publication Statistics
PubMed Score 233.53
PubMed score by year
PubTator Score 108.47
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (84)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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