Tchem FASN Fatty acid synthase

Protein Summary

Description

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49327
• Q13479
• Q16702
• Q4LE83
• Q6P4U5
• Q6SS02
• Q969R1
• Q96C68
• Q96IT0

Gene Name

• FASN

Ensembl ID

• ENST00000306749
• ENSP00000304592
• ENSG00000169710

Symbol

• FAS
• FAS
• OA-519
• SDR27X1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
molecular function	1
protein complex	1
protein domain	1
transcription factor binding site profile	0.96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.81   (req: < 5)

Gene RIFs: 193   (req: <= 3)

Antibodies: 683   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.81   (req: >= 5)

Gene RIFs: 193   (req: > 3)

Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 795

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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orlistat

FASNTchem Enzyme

pKi : 6.55

Active Ligands (795)

Explore Active Ligands

1 – 10 of 795

CHEMBL4084033

FASNTchem Enzyme

pIC50 : 6.8

GSK2194069

FASNTchem Enzyme

pIC50 : 8.11

CHEMBL3623457

FASNTchem Enzyme

pIC50 : 8.52

US8802864, 132

FASNTchem Enzyme

pIC50 : 8.52

US8802864, 42

FASNTchem Enzyme

pIC50 : 8.3

US9428502, 46

FASNTchem Enzyme

pIC50 : 8.3

CHEMBL2147033

FASNTchem Enzyme

pIC50 : 8.22

CHEMBL3623460

FASNTchem Enzyme

pIC50 : 8.22

US8802864, 14

FASNTchem Enzyme

pIC50 : 8.22

US9428502, 7

FASNTchem Enzyme

pIC50 : 8.22

Protein-Protein Interactions (258)

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• See Interactions on String-DB

PTGR2

Tbio

Family:  Enzyme

Novelty:  0.08766092

p_int:  0.996929162

p_ni:  2.78e-7

p_wrong:  0.00307056

Score:  0.712

Data Source:  BioPlex,STRINGDB

HMGB3

Tbio

Family:  TF

Novelty:  0.00474314

p_int:  0.894471609

p_ni:  0.105528391

Data Source:  BioPlex

USP22

Tbio

Family:  Enzyme

Novelty:  0.01416662

p_int:  0.841712131

p_ni:  0.156386723

p_wrong:  0.001901146

Score:  0.225

Data Source:  BioPlex,STRINGDB

ACACA

Tchem

Family:  Enzyme

Novelty:  0.00248313

Score:  0.996

Data Source:  STRINGDB

ACLY

Tclin

Family:  Enzyme

Novelty:  0.00114812

Score:  0.994

Data Source:  STRINGDB

AASDHPPT

Tbio

Family:  Enzyme

Novelty:  0.00443438

Score:  0.99

Data Source:  Reactome,STRINGDB

ACACB

Tchem

Family:  Enzyme

Novelty:  0.00462116

Score:  0.988

Data Source:  STRINGDB

CDC5L

Tbio

Family:  TF

Novelty:  0.00663599

Score:  0.984

Data Source:  STRINGDB

MCAT

Tbio

Family:  Enzyme

Novelty:  0.00600508

Score:  0.962

Data Source:  STRINGDB

ACSL1

Tbio

Family:  Enzyme

Novelty:  0.00336161

Score:  0.961

Data Source:  STRINGDB

Pathways (30)

Reactome (12)

KEGG (5)

PathwayCommons (3)

WikiPathways (10)

Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
Reactome	ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Reactome	Fatty acid metabolism	176 targets	R-HSA-8978868
Reactome	Fatty acyl-CoA biosynthesis	37 targets	R-HSA-75105
Reactome	Integration of energy metabolism	111 targets	R-HSA-163685

Name	Explore in Pharos	Explore in Source
Activation of gene expression by SREBF (SREBP)	42 targets	R-HSA-2426168
ChREBP activates metabolic gene expression	8 targets	R-HSA-163765
Fatty acid metabolism	176 targets	R-HSA-8978868
Fatty acyl-CoA biosynthesis	37 targets	R-HSA-75105
Integration of energy metabolism	111 targets	R-HSA-163685

Gene Ontology Terms (39)

Functions (18)

Components (7)

Processes (14)

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GO Term	Evidence	Assigned by
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
fatty acid synthase activity	Traceable Author Statement (TAS)	Reactome
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
3-oxo-glutaryl-[acp] methyl ester reductase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
3-oxo-pimeloyl-[acp] methyl ester reductase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
3-oxoacyl-[acyl-carrier-protein] synthase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
[acyl-carrier-protein] S-acetyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
[acyl-carrier-protein] S-malonyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

GWAS Traits (9)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	2	5	6		76.5
vital capacity	EFO_0004312	1	1	1		73.2
blood metabolite measurement	EFO_0005664	1	1	1		57.3
forced expiratory volume	EFO_0004314	1	1	1		46.5
smoking status measurement	EFO_0006527	1	1	1		46.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	6		76.5
vital capacity	EFO_0004312	1		73.2
blood metabolite measurement	EFO_0005664	1		57.3
forced expiratory volume	EFO_0004314	1		46.5
smoking status measurement	EFO_0006527	1		46.1

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Fatty acid biosynthesis
Fatty acid metabolism
Hydrolase
Isopeptide bond
Lipid biosynthesis

GWAS Trait Find Similar Targets

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alcohol consumption measurement
birth weight
blood metabolite measurement
BMI-adjusted hip circumference
forced expiratory volume
heel bone mineral density
parental genotype effect measurement
smoking status measurement
vital capacity

MGI Phenotype Find Similar Targets

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adipose tissue phenotype
behavior/neurological phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging
nervous system phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	fatty acid synthase	VGNC:12131	454986
Macaque	fatty acid synthase		715708
Mouse	fatty acid synthase	MGI:95485	14104
Rat	fatty acid synthase	RGD:620665	50671
Dog	fatty acid synthase	VGNC:40736	483378

Species	Name	OMA	EggNOG	Inparanoid
Chimp	fatty acid synthase
Macaque	fatty acid synthase
Mouse	fatty acid synthase
Rat	fatty acid synthase
Dog	fatty acid synthase

Publication Statistics

PubMed Score 791.81

PubMed score by year

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PubTator Score 835.29

PubTator score by year

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