FASN
Fatty acid synthase
Protein Summary
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
- ENST00000306749
- ENSP00000304592
- ENSG00000169710
- FAS
- FAS
- OA-519
- SDR27X1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
molecular function | 1 | ||
protein complex | 1 | ||
protein domain | 1 | ||
transcription factor binding site profile | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 951.23 (req: < 5)
Gene RIFs: 266 (req: <= 3)
Antibodies: 683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 951.23 (req: >= 5)
Gene RIFs: 266 (req: > 3)
Antibodies: 683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 795
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1