Protein Classes
Protein Summary
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
- ENST00000306749
- ENSP00000304592
- ENSG00000169710
- FAS
- FAS
- OA-519
- SDR27X1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
molecular function | 1 | ||
protein complex | 1 | ||
protein domain | 1 | ||
transcription factor binding site profile | 0.96 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 478.52 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 478.52 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 716
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (716)
1 – 10 of 716
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (30)
Reactome (12)
KEGG (5)
PathwayCommons (3)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acyl-CoA biosynthesis | ||||
Reactome | Integration of energy metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
ChREBP activates metabolic gene expression | ||||
Fatty acid metabolism | ||||
Fatty acyl-CoA biosynthesis | ||||
Integration of energy metabolism | ||||
Gene Ontology Terms (39)
Functions (18)
Components (7)
Processes (14)
Items per page:
10
1 – 10 of 18
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (258)
1 – 10 of 258
PTGR2
Family: Enzyme
Novelty: 0.1069009
p_int: 0.996929162
p_ni: 2.78e-7
p_wrong: 0.00307056
Score: 0.712
Data Source: BioPlex,STRINGDB
HMGB3
Family: TF
Novelty: 0.00509708
p_int: 0.894471609
p_ni: 0.105528391
Data Source: BioPlex
USP22
Family: Enzyme
Novelty: 0.01728935
p_int: 0.841712131
p_ni: 0.156386723
p_wrong: 0.001901146
Score: 0.225
Data Source: BioPlex,STRINGDB
ACACA
Family: Enzyme
Novelty: 0.00198949
Score: 0.996
Data Source: STRINGDB
ACLY
Family: Enzyme
Novelty: 0.00135365
Score: 0.994
Data Source: STRINGDB
AASDHPPT
Family: Enzyme
Novelty: 0.00430355
Score: 0.99
Data Source: Reactome,STRINGDB
ACACB
Family: Enzyme
Novelty: 0.00595386
Score: 0.988
Data Source: STRINGDB
CDC5L
Family: TF
Novelty: 0.00617757
Score: 0.984
Data Source: STRINGDB
MCAT
Family: Enzyme
Novelty: 0.01044241
Score: 0.962
Data Source: STRINGDB
ACSL1
Family: Enzyme
Novelty: 0.00272619
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score 478.52
PubMed score by year
PubTator Score 835.29
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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GWAS Trait