Protein Summary
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
- ENST00000306749
- ENSP00000304592
- ENSG00000169710
- FAS
- FAS
- OA-519
- SDR27X1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
molecular function | 1 | ||
protein complex | 1 | ||
protein domain | 1 | ||
transcription factor binding site profile | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 791.81 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 791.81 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 795
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (795)
Protein-Protein Interactions (258)
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (30)
Reactome (12)
KEGG (5)
PathwayCommons (3)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acyl-CoA biosynthesis | ||||
Reactome | Integration of energy metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
ChREBP activates metabolic gene expression | ||||
Fatty acid metabolism | ||||
Fatty acyl-CoA biosynthesis | ||||
Integration of energy metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (18)
Components (7)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 5 | 6 | 76.5 | |||||
vital capacity | 1 | 1 | 1 | 73.2 | |||||
blood metabolite measurement | 1 | 1 | 1 | 57.3 | |||||
forced expiratory volume | 1 | 1 | 1 | 46.5 | |||||
smoking status measurement | 1 | 1 | 1 | 46.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 6 | 76.5 | |||||
vital capacity | 1 | 73.2 | |||||
blood metabolite measurement | 1 | 57.3 | |||||
forced expiratory volume | 1 | 46.5 | |||||
smoking status measurement | 1 | 46.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fatty acid synthase | VGNC:12131 | 454986 | |||||
Macaque | fatty acid synthase | 715708 | ||||||
Mouse | MGI:95485 | 14104 | ||||||
Rat | RGD:620665 | 50671 | ||||||
Dog | fatty acid synthase | VGNC:40736 | 483378 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fatty acid synthase | |||||
Macaque | fatty acid synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | fatty acid synthase | |||||
Publication Statistics
PubMed Score 791.81
PubMed score by year
PubTator Score 835.29
PubTator score by year
Related Publications
Text Mined References (234)
GeneRif Annotations (193)
Items per page:
0 of 0
PMID | Year | Title |
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