You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FASN
Fatty acid synthase

Protein Summary
Description
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306749
  • ENSP00000304592
  • ENSG00000169710

Symbol
  • FAS
  • FAS
  • OA-519
  • SDR27X1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
protein complex
1
protein domain
1
transcription factor binding site profile
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 478.52   (req: < 5)
View Publications
Gene RIFs: 193   (req: <= 3)
View Gene RIFs
Antibodies: 683   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 478.52   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 716
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
42 targets
R-HSA-2426168
Reactome
ChREBP activates metabolic gene expression
8 targets
R-HSA-163765
Reactome
Fatty acid metabolism
176 targets
R-HSA-8978868
Reactome
Fatty acyl-CoA biosynthesis
37 targets
R-HSA-75105
Reactome
Integration of energy metabolism
111 targets
R-HSA-163685
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
42 targets
R-HSA-2426168
ChREBP activates metabolic gene expression
8 targets
R-HSA-163765
Fatty acid metabolism
176 targets
R-HSA-8978868
Fatty acyl-CoA biosynthesis
37 targets
R-HSA-75105
Integration of energy metabolism
111 targets
R-HSA-163685
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
cadherin binding
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
fatty acid synthase activity
Traceable Author Statement (TAS)
Reactome
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
3-oxo-glutaryl-[acp] methyl ester reductase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
3-oxo-pimeloyl-[acp] methyl ester reductase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
3-oxoacyl-[acyl-carrier-protein] synthase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
[acyl-carrier-protein] S-acetyltransferase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
[acyl-carrier-protein] S-malonyltransferase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (258)
1 – 10 of 258
PTGR2
Tbio
Family: Enzyme
Novelty: 0.1069009
p_int: 0.996929162
p_ni: 2.78e-7
p_wrong: 0.00307056
Score: 0.712
Data Source: BioPlex,STRINGDB
HMGB3
Tbio
Family: TF
Novelty: 0.00509708
p_int: 0.894471609
p_ni: 0.105528391
Data Source: BioPlex
USP22
Tbio
Family: Enzyme
Novelty: 0.01728935
p_int: 0.841712131
p_ni: 0.156386723
p_wrong: 0.001901146
Score: 0.225
Data Source: BioPlex,STRINGDB
ACACA
Tchem
Family: Enzyme
Novelty: 0.00198949
Score: 0.996
Data Source: STRINGDB
ACLY
Tclin
Family: Enzyme
Novelty: 0.00135365
Score: 0.994
Data Source: STRINGDB
AASDHPPT
Tbio
Family: Enzyme
Novelty: 0.00430355
Score: 0.99
Data Source: Reactome,STRINGDB
ACACB
Tchem
Family: Enzyme
Novelty: 0.00595386
Score: 0.988
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00617757
Score: 0.984
Data Source: STRINGDB
MCAT
Tbio
Family: Enzyme
Novelty: 0.01044241
Score: 0.962
Data Source: STRINGDB
ACSL1
Tbio
Family: Enzyme
Novelty: 0.00272619
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  478.52

PubMed score by year
PubTator Score  835.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: