Protein Classes
Protein Summary
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
- ENST00000306749
- ENSP00000304592
- ENSG00000169710
- FAS
- FAS
- OA-519
- SDR27X1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
molecular function | 1 | ||
protein complex | 1 | ||
protein domain | 1 | ||
transcription factor binding site profile | 0.96 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 751.02 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 683 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 751.02 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 683 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 716
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (716)
1 – 10 of 716
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fatty acid synthase | VGNC:12131 | 454986 | |||||
Macaque | fatty acid synthase | 715708 | ||||||
Mouse | MGI:95485 | 14104 | ||||||
Rat | RGD:620665 | 50671 | ||||||
Dog | fatty acid synthase | VGNC:40736 | 483378 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fatty acid synthase | |||||
Macaque | fatty acid synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | fatty acid synthase | |||||
Protein Structure (12 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (12)
KEGG (5)
PathwayCommons (3)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | ChREBP activates metabolic gene expression | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Fatty acyl-CoA biosynthesis | ||||
Reactome | Integration of energy metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
ChREBP activates metabolic gene expression | ||||
Fatty acid metabolism | ||||
Fatty acyl-CoA biosynthesis | ||||
Integration of energy metabolism | ||||
Gene Ontology Terms (39)
Functions (18)
Components (7)
Processes (14)
Items per page:
10
1 – 10 of 18
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (258)
1 – 10 of 258
PTGR2
Family: Enzyme
Novelty: 0.08766092
p_int: 0.996929162
p_ni: 2.78e-7
p_wrong: 0.00307056
Score: 0.712
Data Source: BioPlex,STRINGDB
HMGB3
Family: TF
Novelty: 0.00474314
p_int: 0.894471609
p_ni: 0.105528391
Data Source: BioPlex
USP22
Family: Enzyme
Novelty: 0.01416662
p_int: 0.841712131
p_ni: 0.156386723
p_wrong: 0.001901146
Score: 0.225
Data Source: BioPlex,STRINGDB
ACACA
Family: Enzyme
Novelty: 0.00248313
Score: 0.996
Data Source: STRINGDB
ACLY
Family: Enzyme
Novelty: 0.00114812
Score: 0.994
Data Source: STRINGDB
AASDHPPT
Family: Enzyme
Novelty: 0.00443438
Score: 0.99
Data Source: Reactome,STRINGDB
ACACB
Family: Enzyme
Novelty: 0.00462116
Score: 0.988
Data Source: STRINGDB
CDC5L
Family: TF
Novelty: 0.00663599
Score: 0.984
Data Source: STRINGDB
MCAT
Family: Enzyme
Novelty: 0.00600508
Score: 0.962
Data Source: STRINGDB
ACSL1
Family: Enzyme
Novelty: 0.00336161
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score 751.02
PubMed score by year
PubTator Score 835.29
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword