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Tchem
FASN
Fatty acid synthase

Protein Summary
Description
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306749
  • ENSP00000304592
  • ENSG00000169710

Symbol
  • FAS
  • FAS
  • OA-519
  • SDR27X1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
protein complex
1
protein domain
1
transcription factor binding site profile
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.81   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.81   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 795
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (258)
PTGR2
Tbio
Family:  Enzyme
Novelty:  0.08766092
p_int:  0.996929162
p_ni:  2.78e-7
p_wrong:  0.00307056
Score:  0.712
Data Source:  BioPlex,STRINGDB
HMGB3
Tbio
Family:  TF
Novelty:  0.00474314
p_int:  0.894471609
p_ni:  0.105528391
Data Source:  BioPlex
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.841712131
p_ni:  0.156386723
p_wrong:  0.001901146
Score:  0.225
Data Source:  BioPlex,STRINGDB
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
Score:  0.996
Data Source:  STRINGDB
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.994
Data Source:  STRINGDB
AASDHPPT
Tbio
Family:  Enzyme
Novelty:  0.00443438
Score:  0.99
Data Source:  Reactome,STRINGDB
ACACB
Tchem
Family:  Enzyme
Novelty:  0.00462116
Score:  0.988
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.984
Data Source:  STRINGDB
MCAT
Tbio
Family:  Enzyme
Novelty:  0.00600508
Score:  0.962
Data Source:  STRINGDB
ACSL1
Tbio
Family:  Enzyme
Novelty:  0.00336161
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
ADRA1A
Tclin
Family:  GPCR
KEGG Distance:  3
Common Pathways:  1
Pathways (30)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

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1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
ChREBP activates metabolic gene expression
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
ChREBP activates metabolic gene expression
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Integration of energy metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
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Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
76.5
vital capacity
1
1
1
73.2
blood metabolite measurement
1
1
1
57.3
forced expiratory volume
1
1
1
46.5
smoking status measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
vital capacity
1
73.2
blood metabolite measurement
1
57.3
forced expiratory volume
1
46.5
smoking status measurement
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid synthase
VGNC:12131
454986
Macaque
fatty acid synthase
715708
Mouse
MGI:95485
14104
Rat
RGD:620665
50671
Dog
fatty acid synthase
VGNC:40736
483378
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid synthase
Macaque
fatty acid synthase
Mouse
Rat
Dog
fatty acid synthase
Publication Statistics
PubMed Score 791.81
PubMed score by year
PubTator Score 835.29
PubTator score by year
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Related Publications
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PMID
Year
Title