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Tbio
NASP
Nuclear autoantigenic sperm protein

Protein Summary
Description
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350030
  • ENSP00000255120
  • ENSG00000132780
  • ENST00000351223
  • ENSP00000255121
  • ENST00000537798
  • ENSP00000438871

Symbol
  • HMDRA1
  • FLB7527
  • PRO1999
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.95
co-expressed gene
0.87
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.5   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.5   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
41.9
hemoglobin measurement
1
1
1
34.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
41.9
hemoglobin measurement
1
34.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear autoantigenic sperm protein
VGNC:8418
741511
Macaque
alcohol dehydrogenase [Source:RefSeq peptide;Acc:NP_001248287]
Mouse
MGI:1355328
50927
Rat
RGD:1359609
298441
Dog
nuclear autoantigenic sperm protein
VGNC:43626
475373
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear autoantigenic sperm protein
Macaque
alcohol dehydrogenase [Source:RefSeq peptide;Acc:NP_001248287]
Mouse
Rat
Dog
nuclear autoantigenic sperm protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49321-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (180)
1 – 10 of 180
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999992305
p_ni: 0.000007695
Score: 0.986
Data Source: BioPlex,STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999983477
p_ni: 0.000016523
Score: 0.989
Data Source: BioPlex,STRINGDB
ETNK1
Tbio
Family: Kinase
Novelty: 0.04817798
p_int: 0.999683058
p_ni: 0.00031518
p_wrong: 0.000001761
Score: 0.188
Data Source: BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
p_int: 0.999299658
p_ni: 0.000700342
Score: 0.573
Data Source: BioPlex,STRINGDB
H3F3A
Tbio
Novelty: 0.00508186
p_int: 0.990936769
p_ni: 3.5e-8
p_wrong: 0.009063196
Score: 0.647
Data Source: BioPlex,STRINGDB
RBBP4
Tbio
Novelty: 0.01062843
p_int: 0.9318931
p_ni: 0.0681069
Score: 0.972
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.888595874
p_ni: 0.111404126
Score: 0.568
Data Source: BioPlex,STRINGDB
HAT1
Tbio
Family: Epigenetic
Novelty: 0.03621612
Score: 0.991
Data Source: STRINGDB
SLBP
Tbio
Novelty: 0.00685735
Score: 0.984
Data Source: STRINGDB
MCM7
Tbio
Novelty: 0.0017984
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  115.50

PubMed score by year
PubTator Score  35.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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