Tbio NASP Nuclear autoantigenic sperm protein

Protein Summary

Description

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49321
• A8K6H2
• B4DQP3
• D3DQ07
• F5H3J2
• Q53GW5
• Q5T622
• Q5T625
• Q96A69
• Q9BTW2
• NASP

Gene Name

• NASP

Ensembl ID

• ENST00000350030
• ENSP00000255120
• ENSG00000132780
• ENST00000351223
• ENSP00000255121
• ENST00000537798
• ENSP00000438871

Symbol

• HMDRA1
• FLB7527
• PRO1999

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.95
co-expressed gene	0.87
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.78   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.78   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0