MTNR1B
Melatonin receptor type 1B
Protein Summary
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
- ENST00000257068
- ENSP00000257068
- ENSG00000134640
- MT2
- FGQTL2
- MEL-1B-R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
ligand (chemical) | 0.82 | ||
biological term | 0.74 | ||
protein domain | 0.73 | ||
cell type or tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.73 (req: < 5)
Gene RIFs: 165 (req: <= 3)
Antibodies: 310 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.73 (req: >= 5)
Gene RIFs: 165 (req: > 3)
Antibodies: 310 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 736
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4