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Tclin
MTNR1B
Melatonin receptor type 1B

Protein Summary
Description
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257068
  • ENSP00000257068
  • ENSG00000134640

Symbol
  • MT2
  • FGQTL2
  • MEL-1B-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
ligand (chemical)
0.82
biological term
0.74
protein domain
0.73
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.93   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.93   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 704
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
IDG Resources
Mouse
image for
Details:
  • Allele:  Insertion
Genetic Construct
MTNR1B-Tango
image for MTNR1B-Tango
Details:
  • Vector:  addgene66444
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • MTNR1B-Tango
Order Genetic Construct from:
Active Ligands (704)
1 – 10 of 704
5-MeO-DMT
Rendered image for 5-MeO-DMT
2-iodomelatonin
Rendered image for 2-iodomelatonin
IIK7
Rendered image for IIK7
K185
Rendered image for K185
CHEMBL300056
Rendered image for CHEMBL300056
CHEMBL52755
Rendered image for CHEMBL52755
CHEMBL4293386
Rendered image for CHEMBL4293386
CHEMBL4279639
Rendered image for CHEMBL4279639
GWAS Traits (82)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
17
6
21
1.4
99.2
HbA1c measurement
7
5
9
98.2
8
3
5
1.1
94.8
glucose measurement
5
1
5
88.5
body mass index
2
1
2
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
21
1.4
99.2
HbA1c measurement
9
98.2
5
1.1
94.8
glucose measurement
5
88.5
body mass index
2
87.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melatonin receptor 1B
VGNC:3102
466747
Mouse
MGI:2181726
244701
Rat
RGD:620798
192646
Dog
melatonin receptor 1B
VGNC:52269
607818
Horse
melatonin receptor 1B
VGNC:52411
100059172
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melatonin receptor 1B
Mouse
Rat
Dog
melatonin receptor 1B
Horse
melatonin receptor 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49286-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (299)
1 – 10 of 299
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.971
Data Source:  STRINGDB
MTNR1A
Tclin
Family:  GPCR
Novelty:  0.01100617
Score:  0.937
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.937
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.929
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.929
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.928
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.923
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.922
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.922
Data Source:  STRINGDB
ADRA2A
Tclin
Family:  GPCR
Novelty:  0.00273659
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  175.93

PubMed score by year
PubTator Score  136.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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