Tchem SLC11A2 Natural resistance-associated macrophage protein 2

Protein Summary

Description

Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• P49281
• B3KT08
• B4DK84
• F5H741
• O43288
• O60932
• O94801
• Q498Z5
• Q8IUD7
• Q96J35
• NRAMP 2

Gene Name

• SLC11A2

Ensembl ID

• ENST00000262051
• ENSP00000262051
• ENSG00000110911
• ENST00000262052
• ENSP00000262052
• ENST00000394904
• ENSP00000378364
• ENST00000541174
• ENSP00000444542
• ENST00000545993
• ENSP00000442810
• ENST00000546636
• ENSP00000449008
• ENST00000547198
• ENSP00000446769
• ENST00000547688
• ENSP00000449200
• ENST00000644495
• ENSP00000494107
• ENST00000644904
• ENSP00000496105

Symbol

• DCT1
• DMT1
• NRAMP2
• DCT1
• DMT1
• AHMIO1
• NRAMP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
virus perturbation	0.97
disease perturbation	0.95
cellular component	0.92
biological process	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Natural Resistance-associated Macrophage Protein 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc11 Family Of Proton-coupled Metal Ion Transporters / Natural Resistance-associated Macrophage Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.38   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 657.38   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0