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Tchem
SLC11A2
Natural resistance-associated macrophage protein 2

Protein Summary
Description
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria. This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262051
  • ENSP00000262051
  • ENSG00000110911
  • ENST00000262052
  • ENSP00000262052
  • ENST00000394904
  • ENSP00000378364
  • ENST00000541174
  • ENSP00000444542
  • ENST00000545993
  • ENSP00000442810
  • ENST00000546636
  • ENSP00000449008
  • ENST00000547198
  • ENSP00000446769
  • ENST00000547688
  • ENSP00000449200
  • ENST00000644495
  • ENSP00000494107
  • ENST00000644904
  • ENSP00000496105

Symbol
  • DCT1
  • DMT1
  • NRAMP2
  • DCT1
  • DMT1
  • AHMIO1
  • NRAMP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.97
disease perturbation
0.95
cellular component
0.92
biological process
0.91


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.44   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.44   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (31)
1 – 10 of 31
compound 6b [PMID: 22749870]
Rendered image for compound 6b [PMID: 22749870]
CHEMBL3145266
Rendered image for CHEMBL3145266
CHEMBL3145267
Rendered image for CHEMBL3145267
CHEMBL1933782
Rendered image for CHEMBL1933782
CHEMBL3145276
Rendered image for CHEMBL3145276
CHEMBL3145277
Rendered image for CHEMBL3145277
CHEMBL1933791
Rendered image for CHEMBL1933791
CHEMBL3145278
Rendered image for CHEMBL3145278
CHEMBL1933792
Rendered image for CHEMBL1933792
CHEMBL1933793
Rendered image for CHEMBL1933793
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
21.4
appendicular lean mass
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
21.4
appendicular lean mass
1
15.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 11 member 2
VGNC:8533
451897
Macaque
solute carrier family 11 member 2
693986
Mouse
MGI:1345279
18174
Rat
RGD:3684
25715
Dog
solute carrier family 11 member 2
VGNC:46217
486543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 11 member 2
Macaque
solute carrier family 11 member 2
Mouse
Rat
Dog
solute carrier family 11 member 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49281-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) (R-HSA-5619048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Iron uptake and transport
Reactome
Metal ion SLC transporters
Name
Explore in Pharos
Explore in Source
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)
Disease
Disorders of transmembrane transporters
Iron uptake and transport
Metal ion SLC transporters
Gene Ontology Terms (68)
Items per page:
10
1 – 10 of 21
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (110)
1 – 10 of 110
HAMP
Tbio
Novelty:  0.00035828
Score:  0.914
Data Source:  STRINGDB
SLC40A1
Tchem
Family:  Transporter
Novelty:  0.00222468
Score:  0.913
Data Source:  STRINGDB
HEPH
Tbio
Novelty:  0.00609103
Score:  0.898
Data Source:  STRINGDB
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
Score:  0.892
Data Source:  STRINGDB
TFRC
Tbio
Novelty:  0.00025984
Score:  0.863
Data Source:  STRINGDB
HFE
Tbio
Novelty:  0.00042077
Score:  0.839
Data Source:  STRINGDB
VPS35
Tbio
Novelty:  0.00729892
Score:  0.829
Data Source:  STRINGDB
CP
Tbio
Novelty:  0.00103285
Score:  0.825
Data Source:  STRINGDB
SLC39A14
Tbio
Family:  Transporter
Novelty:  0.01053215
Score:  0.823
Data Source:  STRINGDB
ACO1
Tbio
Family:  Enzyme
Novelty:  0.00194023
Score:  0.818
Data Source:  STRINGDB
Publication Statistics
PubMed Score  578.44

PubMed score by year
PubTator Score  258.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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