Tbio SLC11A1 Natural resistance-associated macrophage protein 1

Protein Summary

Description

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49279
• C0H5Y3
• NRAMP 1

Gene Name

• SLC11A1

Ensembl ID

• ENST00000233202
• ENSP00000233202
• ENSG00000018280

Symbol

• LSH
• NRAMP
• NRAMP1
• LSH
• NRAMP
• NRAMP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.93
cellular component	0.89
molecular function	0.84
biological term	0.76

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Natural Resistance-associated Macrophage Protein 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc11 Family Of Proton-coupled Metal Ion Transporters / Natural Resistance-associated Macrophage Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1016.37   (req: < 5)

Gene RIFs: 147   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1016.37   (req: >= 5)

Gene RIFs: 147   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0